Is 2-Cyclohexylethyl Acetate safe in cosmetics?
2-Cyclohexylethyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Cyclohexylethyl Acetate
Also known as: FEMA 2348, BRN 2244135, Cyclohexane ethyl acetate, Cyclohexaneethanol acetate, Cyclohexylethyl acetate (+6 more)
INCI: 2-CYCLOHEXYLETHYL ACETATE
2-Cyclohexylethyl Acetate (CAS 21722-83-8) is a cosmetic cosmetic ingredient functioning as Flavouring, Fragrance (sweet-fruity, mint, rose, raspberry notes). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 21722-83-8 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring, Fragrance (sweet-fruity, mint, rose, raspberry notes)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-cyclohexylethyl acetate
InChIKey
NOTFZGFABLVTIG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS for flavoring; no FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Cyclohexylethyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
964
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXANEETHYL ACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXAHYDROPHENETHYL ACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXYLETHYL ACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/41 | FAS 50-JECFA 59/173
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Cyclohexylethyl Acetate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
FEMA 2348
BRN 2244135
Cyclohexane ethyl acetate
Cyclohexaneethanol acetate
Cyclohexylethyl acetate
EINECS 244-543-3
Ethylcyclohexyl acetate
FEMA No. 2348
Hexahydrophenethyl acetate
Hexahydrophenyl ethyl acetate
UNII-15W91S5XTZ
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3560993
Frequently Asked Questions
Is 2-Cyclohexylethyl Acetate allowed in the EU?
2-Cyclohexylethyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Cyclohexylethyl Acetate do in cosmetics?
2-Cyclohexylethyl Acetate functions as: Flavouring, Fragrance (sweet-fruity, mint, rose, raspberry notes). It is classified as a cosmetic ingredient in our database. CAS number: 21722-83-8.
Is 2-Cyclohexylethyl Acetate used outside cosmetics?
2-Cyclohexylethyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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