Is 2-Amino-5-Ethylphenol HCl safe in cosmetics?
2-Amino-5-Ethylphenol HCl has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Amino-5-Ethylphenol HCl
Also known as: UNII-B5IWK1V8FX, Colorex AEP, Phenol, 2-amino-5-ethyl-, hydrochloride
INCI: 2-AMINO-5-ETHYLPHENOL HCL
2-Amino-5-Ethylphenol HCl (CAS 149861-22-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative hair dye precursor. Reported NOAEL =0.026 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 149861-22-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Amino-5-Ethylphenol HCl is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H314, H315, H317, H319, H335, H400, H410).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing — oxidative hair dye precursor
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-amino-5-ethylphenol;hydrochloride
InChIKey
SZAJCDAIQPZDSA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted for use; limited to oxidative hair dyes
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-5-Ethylphenol HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Amino-5-Ethylphenol HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.026 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.026 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.026 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.026 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/day | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/day | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/day | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =16 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
No longer valid
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 2.7% | - | - | 2012-03-27 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "149861-22-3", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "173.64", "color_result_on_hair": "Red modifier", "shade_range": "red", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "sensitizati…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 2-Amino-5-Ethylphenol HCl.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Amino-5-Ethylphenol HCl by CAS number or substance name.
Studies
20
Lowest NOAEL
0.026
Highest NOAEL
369
Units vary across source rows: mg/kg bw/day, mg/kg bw/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.7% | SCCS opinion extraction | - |
Known Synonyms
UNII-B5IWK1V8FX
Colorex AEP
Phenol, 2-amino-5-ethyl-, hydrochloride
Chemical Function
Dye
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1...
Frequently Asked Questions
Is 2-Amino-5-Ethylphenol HCl allowed in the EU?
2-Amino-5-Ethylphenol HCl EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-5-Ethylphenol HCl do in cosmetics?
2-Amino-5-Ethylphenol HCl functions as: Hair dyeing — oxidative hair dye precursor. It is classified as a cosmetic ingredient in our database. CAS number: 149861-22-3.
What is the NOAEL for 2-Amino-5-Ethylphenol HCl?
The NOAEL (No Observed Adverse Effect Level) for 2-Amino-5-Ethylphenol HCl is =0.026 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 2-Amino-5-Ethylphenol HCl used outside cosmetics?
2-Amino-5-Ethylphenol HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Amino-5-Ethylphenol HCl have different safety status in cosmetics vs industrial chemicals?
2-Amino-5-Ethylphenol HCl is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H314, H315, H317, H319, H335, H400, H410).
Compliance Tools
Check 2-Amino-5-Ethylphenol HCl compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
2-ACRYLAMIDO-2-METHYLPROPANE SULFONIC ACID
Moderate
Browse nearby
Not Reported
2-Acetonaphthone
Moderate
Browse nearby
Masking, Perfuming
2-Acetylhydroquinone
Moderate
Browse nearby
Antioxidant
Is 2-Amino-5-Ethylphenol HCl in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-5-Ethylphenol HCl in your formulation.