Danger GHS06GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

1,6-Diisocyanatohexane

Also known as: 1,6-Hexamethylene diisocyanate, 1,6-Diisocyanatohexamethylene, HMDI, NSC 11687, MODIFIED HEXAMETHYL DIISOCYANATE (+12 more)

CAS 822-06-0

1,6-Diisocyanatohexane (CAS 822-06-0) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H335; H315; H319; H334; H317. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for 1,6-Hexamethylene Diisocyanate (HDI) →

Cross-Vertical Regulatory Divergence

1,6-Diisocyanatohexane is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H335, H315, H319, H334, H317).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

1,6-Diisocyanatohexane

CAS Number

822-06-0

DTXSID

DTXSID4024143

Molecular Formula

C8H12N2O2

InChI Key

RRAMGCGOFNQTLD-UHFFFAOYSA-N

Monoisotopic Mass

168.089878

Synonyms

1,6-Hexamethylene diisocyanate1,6-DiisocyanatohexamethyleneHMDINSC 11687MODIFIED HEXAMETHYL DIISOCYANATEUN 2281BRN 0956709EINECS 212-485-8Isocyanic acid, diester with 1,6-hexanediolHexamethylendiisokyanatMetyleno-bis-fenyloizocyjanianSzesciometylenodwuizocyjanian

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1	H331; H335; H315; H319; H334; H317	GHS06; GHS08	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction
Short-term Effects	The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 4 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	0.005 ppm (0.035 mg/m³)	0.005	0.035	N
NIOSH	CEILING	0.020 ppm (0.140 mg/m³) [10 minutes]	0.02	0.14	N
ACGIH	TWA	0.005 ppm [1985]	0.005	-	N
CAL/OSHA	TWA	0.005 ppm (0.034 mg/m³)	0.005	0.034	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 21 records

MonomersSolventChemical reaction regulatorCatalystPolymerization promoterHardenerNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Cons electronics mech appliances and machinery; Europe; nondetect	Danish EPA	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 54 studies

Value	Unit	Endpoint	Route	Species	Source
range123.496	ug/mL	CD86, EC120	Dermal	-	NTP_ICE_skin_sensitization
=0.035	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
84.4	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
49.1	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
range74.32	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
0.03	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0I70A3I1UF	UNII	FDA UNII substance identifier	-	-	openFDA substances
0I70A3I1UF	UNII	FDA UNII substance identifier	-	-	openFDA substances
0I70A3I1UF	UNII	FDA UNII substance identifier	-	-	openFDA substances
0I70A3I1UF	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.124	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.462	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=738	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=0.687922	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1.19	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=1.54	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=2.45	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=2.5	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=6.71	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=9.93	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=11.6259	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=280	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=490	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=0.120386	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2.06377	mg/m3	LOAEC	inhalation	Guinea Pig	ToxValDB_ECHA_IUCLID
=3.16444	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.00619129	mg/m3	LOAEL	inhalation	Rat (Fischer 344; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.0343961	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.0343961	mg/m3	LOAEL	inhalation	Rat (Fischer 344; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.0687922	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.175	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=0.03	mg/m3	LOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=0.005	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_IRIS
=0.00619129	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.0000687922	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.000206376	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=0.687922	mg/m3	NOAEC	inhalation	Guinea Pig	ToxValDB_ECHA_IUCLID
=1.12819	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2.06377	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.00619129	mg/m3	NOAEL	inhalation	Rat (Sprague Dawley; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.0343961	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.0343961	mg/m3	NOAEL	inhalation	Rat (Sprague Dawley; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.035	mg/m3	NOAEL	inhalation	Rat	ToxValDB_IRIS
=0.185739	mg/m3	NOAEL	inhalation	Rat	ToxValDB_TX_TCEQ
=0.006	mg/m3	NOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=0.001	mg/m3	NOAEL (HEC)	inhalation	Rat	ToxValDB_IRIS
=0.001	mg/m^3	NOAEL (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=0.00619129	mg/m3	NOAEL (HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.0343961	mg/m3	NOEL	inhalation	Rat	ToxValDB_ECHA_IUCLID

Showing 50 of 54 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Hexamethylene diisocyanate	212-485-8	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Hexamethylene-1,6-diisocyanate (HDI)	N120 - Diisocyanates	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1896533

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane (CAS 822-06-0) is classified under EU CLP Annex VI as Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H331; H335; H315; H319; H334; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane has 54 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include 1,6-Diisocyanatohexane?

1,6-Diisocyanatohexane appears on 6 regulatory/inventory lists including detected; Europe; Toys and children's products, Europe; Toys and children's products, CEDI, and 3 more. Source: EPA CPDat.

What are the occupational exposure limits for 1,6-Diisocyanatohexane?

Occupational exposure limits for 1,6-Diisocyanatohexane are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,6-Diisocyanatohexane used in cosmetics?

Yes, 1,6-Diisocyanatohexane is also indexed as a cosmetic ingredient under the name 1,6-Hexamethylene Diisocyanate (HDI). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,6-Diisocyanatohexane come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,6-Diisocyanatohexane have different safety status in cosmetics vs industrial chemicals?

1,6-Diisocyanatohexane is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H335, H315, H319, H334, H317).

Is 1,6-Diisocyanatohexane used outside industrial chemicals?

1,6-Diisocyanatohexane also appears in cosmetics, pharmaceutical databases.