Also known as: EINECS 232-627-2, Vegetable pepsin, Papaya Enzyme, EC 3.4.22.2, UNII-A236A06Y32
CAS 9001-73-4
Papain (CAS 9001-73-4) is a chemical substance with GHS signal word Danger; key hazard signal: H335; H315; H319; H334. Key regulatory status: 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.
Papain is classified GHS Danger (H335, H315, H319, H334) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1 | H335; H315; H319; H334 | GHS07; GHS08 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| A236A06Y32 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A236A06Y32 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A236A06Y32 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A236A06Y32 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >4000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 375 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 488 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 800 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 820 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1080 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 12 of 12 studies
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
E1101ii — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Papain (CAS 9001-73-4) is classified under EU CLP Annex VI as STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1 with signal word Danger. Hazard statements: H335; H315; H319; H334. Source: EU CLP Annex VI (ECHA).
Papain has 12 NOAEL studies in the database. The lowest reported value is A236A06Y32 UNII. Source: openFDA substances.
Papain appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, animal_products, and 3 more. Source: EPA CPDat.
Yes, Papain is also indexed as a cosmetic ingredient under the name Papain. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Papain is classified GHS Danger (H335, H315, H319, H334) in the chemicals database but is allowed in EU cosmetics.
Papain also appears in cosmetics, food safety databases.