What is the NOAEL for D-Mannitol?
D-Mannitol has 43 NOAEL studies in the database. The lowest reported value is 50 mg/kg bw/day. Source: INCHEM_WHO_jecfa_jecmono_v21je10.
NOAEL Data
Cosmetic Ingredient
D-Mannitol
Also known as: Mannitol, 4-01-00-02841, BRN 1721898, EINECS 200-711-8, NCI-C50362 (+15 more)
CAS 69-65-8
D-Mannitol (CAS 69-65-8) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
43
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
D-Mannitol
CAS Number
69-65-8
DTXSID
DTXSID1023235
Molecular Formula
C6H14O6
InChI Key
FBPFZTCFMRRESA-KVTDHHQDSA-N
Monoisotopic Mass
182.079038
Synonyms
Mannitol4-01-00-02841BRN 1721898EINECS 200-711-8NCI-C50362NSC 407017Mannitol 10%Mannitol 10% in plastic containerMannitol 10% w/ dextrose 5% in distilled waterMannitol 15%Mannitol 15% in plastic containerMannitol 15% w/ dextrose 5% in sodium chloride 0.45%
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
HumectantDeodorizerSoftener and conditionerBinderFragranceFlavouring and nutrientProcessing aids not otherwise specifiedSolventAnti-caking agentLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 43 of 43 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-5050 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v21je10 |
| range:0-5050 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v21je10 |
| 3OWL53L36A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3OWL53L36A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3OWL53L36A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3OWL53L36A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| =13500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =1250 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >2500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| >2500 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =7500 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =7500 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =2500 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1250 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =1250 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =3750 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
| =3750 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 50000 | ppm | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
Showing 43 of 43 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
MANNITOL
ChEMBL Phase
4
Adverse Events
1561
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E421 — ADI: 10 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include D-Mannitol?
D-Mannitol appears on 3 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is D-Mannitol used in cosmetics?
Yes, D-Mannitol is also indexed as a cosmetic ingredient under the name Mannitol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-Mannitol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is D-Mannitol used outside industrial chemicals?
D-Mannitol also appears in cosmetics, pharmaceutical, food safety databases.