ParenteralTopicalDosed ingredientTherapeutic flag
Cosmetic cross-reference
Mannitol
CAS 69-65-8
Mannitol (CAS 69-65-8) is a Phase 4 pharmaceutical compound with 3 bioactivity targets and 1,561 adverse event associations.
SOURCE
NLM DailyMed
Label records
0
SOURCE
EMBL-EBI ChEMBL
Bioactivity
3
SOURCE
DrugCentral / FAERS
Adverse signals
1,561
SOURCE
IUPHAR / PharmGKB
PubMed IDs
0
SOURCE
ChEMBL 36
B25820EEF0F0
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Primary Name
Mannitol
CAS Number
69-65-8
UNII
3OWL53L36A
InChIKey
FBPFZTCFMRRESA-KVTDHHQDSA-N
ChEMBL ID
CHEMBL689
Molecule Type
Small molecule
Source Match
EMBL-EBI ChEMBL (INCHIKEY)
dosed ingredientnatural productparenteraltherapeutic flagtopical
SOURCE
ChEMBL 36
B25820EEF0F0
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Phase 4 (Approved)
Approved or marketed human pharmaceutical use is represented in the source phase field.
ChEMBL CHEMBL689 | Small molecule
SOURCE
Ingredients table / CosIng profile
same-CAS cross-reference
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
SOURCE
ChEMBL 36 activities + assays
3 bioactivity rows
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | AC50 | 28252.59487179487 nM | 39 | - |
| - | Potency | 20496.522222222222 nM | 9 | - |
| - | IC50 | 30000 nM | 3 | - |
SOURCE
DrugCentral 2023 / FAERS disproportionality
80 associations
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Renal injury | 178 | 510.598 | 10061481 |
| Fear | 179 | 503.089 | 10016275 |
| Anhedonia | 135 | 390.47 | 10002511 |
| Renal impairment | 281 | 379.969 | 10062237 |
| Emotional distress | 162 | 348.18 | 10049119 |
| Multiple organ dysfunction syndrome | 234 | 345.732 | 10077361 |
| Injury | 199 | 326.318 | 10022116 |
| Stress | 200 | 325.568 | 10042209 |
| Unevaluable event | 184 | 314.362 | 10062355 |
| Renal failure | 266 | 276.237 | 10038435 |
| Appendicolith | 68 | 197.795 | 10074458 |
| Blood phosphorus increased | 66 | 174.021 | 10050196 |
| Anxiety | 220 | 153.917 | 10002855 |
| Appendicitis | 69 | 134.762 | 10003011 |
| Ventricular fibrillation | 77 | 130.19 | 10047290 |
| Brain oedema | 71 | 129.928 | 10048962 |
| Cardiogenic shock | 79 | 117.687 | 10007625 |
| Oropharyngeal cancer | 19 | 92.077 | 10031096 |
| Hyponatraemia | 132 | 89.16 | 10021036 |
| Maculopathy | 28 | 81.86 | 10025425 |
| Blood uric acid increased | 42 | 78.818 | 10005861 |
| Incision site pain | 26 | 77.257 | 10058043 |
| Brain herniation | 32 | 72.654 | 10006126 |
| Ascites | 81 | 72.545 | 10003445 |
| Sepsis | 160 | 69.589 | 10040047 |
| Myasthenia gravis | 35 | 68.592 | 10028417 |
| Acute kidney injury | 223 | 65.745 | 10069339 |
| Lip and/or oral cavity cancer | 19 | 64.365 | 10061523 |
| Arthralgia | 23 | 62.32 | 10003239 |
| Lymphocyte count decreased | 56 | 57.656 | 10025256 |
| Red blood cells urine positive | 24 | 57.398 | 10038182 |
| Propofol infusion syndrome | 18 | 55.07 | 10063181 |
| Blood urea increased | 55 | 54.234 | 10005851 |
| Fatigue | 77 | 53.819 | 10016256 |
| Cerebral haemorrhage | 60 | 53.782 | 10008111 |
| Abdominal distension | 89 | 53.643 | 10000060 |
| Blood creatinine increased | 101 | 53.21 | 10005483 |
| Fear of death | 17 | 52.6 | 10066392 |
| Protein urine present | 28 | 49.026 | 10053123 |
| Dry mouth | 72 | 46.268 | 10013781 |
| Fall | 19 | 45.254 | 10016173 |
| Hyperkalaemia | 75 | 44.836 | 10020646 |
| Hypophosphataemia | 32 | 40.105 | 10021058 |
| Abdominal discomfort | 8 | 39.857 | 10000059 |
| Peripheral swelling | 5 | 38.857 | 10048959 |
| Hyperphosphataemia | 20 | 38.549 | 10020711 |
| Tick-borne viral encephalitis | 8 | 36.531 | 10043847 |
| Rheumatoid arthritis | 4 | 35.964 | 10039073 |
| Complications of transplanted kidney | 19 | 35.578 | 10010185 |
| Neutrophil count increased | 35 | 35.462 | 10029368 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
SOURCE
RxNorm drug names
4 name rows
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| Mannitol | 6628 | SU | MTHSPL |
| mannitol | 6628 | SU | MTHSPL |
| MANNITOL | 6628 | SU | MTHSPL |
| mannitol | 6628 | IN | RXNORM |
SOURCE
SIDER side-effect resource
80 side-effect rows
Side Effects
SIDER side-effect terms mapped to the drug or same-CAS compound identity.
| Side Effect | Drug Name | MedDRA Type | Concept ID |
|---|---|---|---|
| Abdominal pain upper | mannitol | LLT | C0232492 |
| Abdominal pain upper | mannitol | PT | C0232492 |
| Acidosis | mannitol | LLT | C0001122 |
| Acidosis | mannitol | PT | C0001122 |
| Acidosis | mannitol | LLT | C0001122 |
| Acidosis | mannitol | PT | C0001122 |
| Acne | mannitol | LLT | C0702166 |
| Acne | mannitol | PT | C0702166 |
| Angina pectoris | mannitol | LLT | C0002962 |
| Angina pectoris | mannitol | PT | C0002962 |
| Angina pectoris | mannitol | LLT | C0002962 |
| Angina pectoris | mannitol | PT | C0002962 |
| Arthralgia | mannitol | LLT | C0003862 |
| Arthralgia | mannitol | PT | C0003862 |
| Asthenia | mannitol | PT | C0004093 |
| Back pain | mannitol | LLT | C0004604 |
| Back pain | mannitol | PT | C0004604 |
| Back pain | mannitol | LLT | C0004604 |
| Back pain | mannitol | PT | C0004604 |
| Bacterial disease carrier | mannitol | LLT | C0853960 |
| Bacterial disease carrier | mannitol | PT | C0853960 |
| Blood alkaline phosphatase increased | mannitol | LLT | C0852911 |
| Blood alkaline phosphatase increased | mannitol | PT | C0852911 |
| Body temperature increased | mannitol | LLT | C0015967 |
| Body temperature increased | mannitol | PT | C0015967 |
| Bronchitis | mannitol | LLT | C0006277 |
| Bronchitis | mannitol | PT | C0006277 |
| Bronchopneumonia | mannitol | LLT | C0006285 |
| Bronchopneumonia | mannitol | PT | C0006285 |
| Bronchospasm | mannitol | LLT | C0006266 |
| Bronchospasm | mannitol | PT | C0006266 |
| Candida infection | mannitol | PT | C0006840 |
| Cardiac failure | mannitol | LLT | C0018801 |
| Cardiac failure | mannitol | PT | C0018801 |
| Cardiac failure | mannitol | PT | C0018801 |
| Cardiac failure congestive | mannitol | LLT | C0018802 |
| Cardiac failure congestive | mannitol | PT | C0018802 |
| Chest discomfort | mannitol | LLT | C0235710 |
| Chest discomfort | mannitol | PT | C0235710 |
| Chest pain | mannitol | LLT | C0008031 |
| Chest pain | mannitol | PT | C0008031 |
| Chest pain | mannitol | PT | C0008031 |
| Chills | mannitol | LLT | C0085593 |
| Chills | mannitol | PT | C0085593 |
| Chills | mannitol | LLT | C0085593 |
| Chills | mannitol | PT | C0085593 |
| Cold sweat | mannitol | LLT | C0232431 |
| Cold sweat | mannitol | PT | C0232431 |
| Condition aggravated | mannitol | LLT | C0235874 |
| Condition aggravated | mannitol | PT | C0235874 |
| Connective tissue disorder | mannitol | LLT | C0009782 |
| Connective tissue disorder | mannitol | PT | C0009782 |
| Convulsion | mannitol | LLT | C0036572 |
| Convulsion | mannitol | PT | C0036572 |
| Convulsion | mannitol | LLT | C0036572 |
| Convulsion | mannitol | PT | C0036572 |
| Cough | mannitol | LLT | C0010200 |
| Cough | mannitol | PT | C0010200 |
| Decompensation cardiac | mannitol | LLT | C1961112 |
| Decreased appetite | mannitol | LLT | C0232462 |
| Decreased appetite | mannitol | PT | C0232462 |
| Dehydration | mannitol | LLT | C0011175 |
| Dehydration | mannitol | PT | C0011175 |
| Dehydration | mannitol | LLT | C0011175 |
| Dehydration | mannitol | PT | C0011175 |
| Dermatitis | mannitol | PT | C0011603 |
| Diabetes mellitus | mannitol | LLT | C0011849 |
| Diabetes mellitus | mannitol | PT | C0011849 |
| Diarrhoea | mannitol | LLT | C0011991 |
| Diarrhoea | mannitol | PT | C0011991 |
| Diarrhoea | mannitol | LLT | C0011991 |
| Diarrhoea | mannitol | PT | C0011991 |
| Discomfort | mannitol | PT | C0234215 |
| Diuresis | mannitol | LLT | C0012797 |
| Diuresis | mannitol | LLT | C0012797 |
| Dizziness | mannitol | LLT | C0012833 |
| Dizziness | mannitol | PT | C0012833 |
| Dysphonia | mannitol | LLT | C1527344 |
| Dysphonia | mannitol | PT | C1527344 |
| Dyspnoea | mannitol | LLT | C0013404 |
SOURCE
Rendered pharma page rows
FAQPage JSON-LD
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Mannitol used for in pharmaceutical contexts?
Mannitol (CAS 69-65-8) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Mannitol?
Mannitol has 1,561 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Renal injury, Fear, Anhedonia, Renal impairment, Emotional distress. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Mannitol also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Mannitol with EU status "permitted".
What clinical phase is Mannitol in?
Mannitol is rendered with ChEMBL max phase 4 (approved).