Food Safety Substance
D-MannitolE421
D-Mannitol (E421) is a food additive with PUBLISHED in the EU, GRAS in the US, and data from 6 regulatory sources.
CAS 69-65-8
E421
Indexable evidence set
FDA
GRAS
ADI / TDI
ADI 10 mg/kg bw
Codex
18 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 6 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
D-Mannitol
CAS
69-65-8
E-number
E421
DTXSID
DTXSID1023235
PubChem CID
6251
Evidence tier
Indexable evidence set (13)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | PUBLISHED | EU additive listing; Annex II entry |
| Codex | Codex Alimentarius | Listed | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener |
SOURCE
EU Commission
EU Food Additives | EU Food Additives Database
EU Food Additive Status
EU Commission food-additive listing rows from eu_food_additives.
| Jurisdiction | E-number | Status | Type | Name | Note |
|---|---|---|---|---|---|
| European Union | E421 | PUBLISHED | substanceFAD | Mannitol | - |
SOURCE
EU Commission
EU Annex II Authorised | EU Food Additives Database
EU Annex II Authorised Uses
Authorised additive rows and use conditions from EU Annex II tables.
| Jurisdiction | E-number | Name | INS | Policy item | Note |
|---|---|---|---|---|---|
| European Union | E421 | Mannitol | - | POL-FAD-IMPORT-3145 | - |
Conditions and restrictions
| Jurisdiction | Food category | Restriction | Comment | Source |
|---|---|---|---|---|
| European Union | 13.1 foods for infants and young children | - | 1 000 times more than vitamin B12, 3 mg/kg total carry-over | EU Annex II Union List |
| European Union | 13.1 foods for infants and young children | - | 1 000 times more than vitamin B12, 3 mg/kg total carry-over | EU Food Additives Database |
SOURCE
Codex Alimentarius
Codex GSFA
Codex GSFA Status
Codex Alimentarius GSFA permissions and maximum-use rows.
| Jurisdiction | INS / E-number | Function | Food category | Max level | Notes |
|---|---|---|---|---|---|
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 01.2.2 Renneted milk (plain) | GMP | - |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 06.4.2 Dried pastas and noodles and like products | GMP | For use in noodles, gluten-free pasta and pasta intended for hypoproteic diets only. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 08.1.1 Fresh meat, poultry, and game, whole pieces or cuts | GMP | For use in glaze, coatings or decorations for fruit, vegetables, meat or fish only.; For use in fresh meat, poultry and game products only. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 08.1.2 Fresh meat, poultry, and game, comminuted | GMP | For use in fresh minced meat which contains other ingredients apart from comminuted meat only. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.1 Frozen fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | GMP | Excluding products conforming to the Standard for Fresh and Quick Frozen Raw Scallop Products (CODEX STAN 315-2014).; Excluding products conforming to the Standard for Quick... |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.2 Frozen battered fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | GMP | Excluding products conforming to the Standard for Quick Frozen Fish Sticks (Fish Fingers), Fish Portions and Fish Fillets – Breaded or in Batter (CODEX STAN 166-1989). |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.3 Frozen minced and creamed fish products, including mollusks, crustaceans, and echinoderms | GMP | - |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.4.1 Cooked fish and fish products | GMP | For use in surimi products only. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.4.3 Fried fish and fish products, including mollusks, crustaceans, and echinoderms | GMP | For use in breading or batter coatings only. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including mollusks, crustaceans, and echinoderms | GMP | Excluding products conforming to the Standard for Crackers from Marine and Freshwater Fish, Crustaceans and Molluscan Shellfish (CODEX STAN 222-2001).; Excluding products... |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 10.2.2 Frozen egg products | GMP | - |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 11.4 Other sugars and syrups (e.g. xylose, maple syrup, sugar toppings) | GMP | Excluding maple syrup. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 12.1.2 Salt Substitutes | GMP | - |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 12.2.1 Herbs and spices | GMP | For herbs use is limited to herbs that have been ground or processed into powder only, as an anticaking agent.; Excluding products conforming to the Standard for Black, White and... |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 13.1.1 Infant formulae | 10 mg/kg | As consumed.; Maximum use level is expressed as mg additive/L of food.; For use as a nutrient carrier in a raw material or other ingredient. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 13.1.2 Follow-up formulae | 10 mg/kg | As consumed.; Maximum use level is expressed as mg additive/L of food.; For use as a nutrient carrier in a raw material or other ingredient. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 13.1.3 Formulae for special medical purposes for infants | 10 mg/kg | As consumed.; Maximum use level is expressed as mg additive/L of food.; For use as a nutrient carrier in a raw material or other ingredient. |
| Codex | 421 | Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener | 13.2 Complementary foods for infants and young children | 10 mg/kg | For use as a nutrient carrier in a raw material or other ingredient used to produce the foods conforming to the Standard for Processed Cereal-Based Foods for Infants and Young... |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | MANNITOL | - | 69-65-8 | NOT SPECIFIED | - | TEXTURIZER, THICKENER, BULKING_AGENT, HUMECTANT, STABILIZER, SWEETENER | 1986 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is D-Mannitol used for in food?
D-Mannitol appears in food-use rows as: Sweetener; Anticaking agent; Bulking agent; Carrier; Humectant; Stabilizer; Sweetener; Thickener.
Is D-Mannitol / E421 safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI 10 mg/kg bw. EU status evidence: PUBLISHED. US/FDA evidence: GRAS.
What is the ADI for D-Mannitol?
D-Mannitol has this ADI/reference value in the food-safety tables: ADI 10 mg/kg bw. Source: JECFA / EFSA (re-evaluation ongoing).
Is D-Mannitol also used in cosmetics?
D-Mannitol has a same-CAS cosmetics cross-reference: Mannitol, EU status permitted.