OralDosed ingredientTherapeutic flag Cosmetic cross-reference

Isosorbide

CAS 652-67-5

Isosorbide (CAS 652-67-5) is a Phase 4 pharmaceutical compound with 3 bioactivity targets and 611 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral / FAERS

Adverse signals

611

SOURCE IUPHAR / PharmGKB

PubMed IDs

SOURCE ChEMBL 36 B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Isosorbide

CAS Number

652-67-5

UNII

WXR179L51S

InChIKey

KLDXJTOLSGUMSJ-JGWLITMVSA-N

ChEMBL ID

CHEMBL1200660

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

dosed ingredientnatural productoraltherapeutic flag

SOURCE ChEMBL 36 B25820EEF0F0

Clinical Development Phase

Highest clinical development phase rendered from the matched compound identifier rows.

Phase 4 (Approved)

Approved or marketed human pharmaceutical use is represented in the source phase field.

ChEMBL CHEMBL1200660 | Small molecule

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE ChEMBL 36 activities + assays 3 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	AC50	2929.75 nM	6	-
-	Potency	17706.116666666665 nM	6	-
-	IC50	19976.309999999998 nM	1	-

SOURCE DrugCentral 2023 / FAERS disproportionality 80 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Cardiospasm	133	467.407	10007645
Palmoplantar keratoderma	132	446.253	10033554
Pruritus genital	131	414.115	10037093
Myocardial infarction	469	412.703	10028596
Sleep terror	131	409.35	10041010
Carotid artery occlusion	139	377.039	10048964
Atrial tachycardia	136	375.18	10003668
Tension headache	135	366.42	10043269
Anosmia	134	326.277	10002653
Subarachnoid haemorrhage	173	319.157	10042316
Immunisation	86	301.852	10021430
Facial pain	135	297.378	10016059
Cardiac failure congestive	333	270.651	10007559
Pain of skin	133	264.523	10033474
Ventricular tachycardia	176	241.127	10047302
Chest pain	453	236.074	10008479
Vasculitis	142	216.041	10047115
Eye pruritus	133	215.343	10052140
Transient ischaemic attack	188	214.212	10044390
Muscle twitching	137	209.212	10028347
Blindness	148	192.429	10005169
Lip swelling	146	172.889	10024570
Diplopia	140	167.895	10013036
Drug ineffective	233	157.263	10013709
Hallucination	193	143.741	10019063
Rash papular	102	143.434	10037876
Amnesia	166	138.84	10001949
Tinnitus	144	138.374	10043882
Disturbance in attention	146	136.203	10013496
Blood glucose increased	222	134.56	10005557
Angioedema	162	126.105	10002424
Coronary artery disease	154	125.513	10011078
Dry skin	162	124.649	10013786
Intentional product misuse	173	114.213	10074903
Acute myocardial infarction	152	113.201	10000891
Cognitive disorder	148	103.451	10057668
Angina unstable	71	97.575	10002388
Visual impairment	171	95.675	10047571
Treatment failure	3	92.659	10066901
Dehydration	289	90.771	10012174
Hyperhidrosis	213	89.778	10020642
Palpitations	189	87.955	10033557
Joint swelling	27	85.292	10023232
Drug intolerance	26	82.849	10061822
Infusion related reaction	16	82.368	10051792
Angina pectoris	108	77.6	10002383
Heart rate increased	174	74.314	10019303
Systemic lupus erythematosus	5	73.162	10042945
Arthropathy	12	72.316	10003285
Feeling abnormal	212	71.722	10016322

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE RxNorm drug names 2 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
ISOSORBIDE	6057	SU	MTHSPL
isosorbide	6057	IN	RXNORM

SOURCE SIDER side-effect resource 41 side-effect rows

Side Effects

SIDER side-effect terms mapped to the drug or same-CAS compound identity.

Side Effect	Drug Name	MedDRA Type	Concept ID
Angina pectoris	isosorbide	PT	C0002962
Angina unstable	isosorbide	LLT	C0002965
Angina unstable	isosorbide	PT	C0002965
Bradycardia	isosorbide	LLT	C0428977
Bradycardia	isosorbide	PT	C0428977
Dermatitis	isosorbide	PT	C0011603
Dermatitis exfoliative	isosorbide	LLT	C0011606
Dermatitis exfoliative	isosorbide	PT	C0011606
Dizziness	isosorbide	LLT	C0012833
Dizziness	isosorbide	PT	C0012833
Dizziness	isosorbide	PT	C0012833
Dizziness	isosorbide	PT	C0012833
Flushing	isosorbide	LLT	C0016382
Flushing	isosorbide	PT	C0016382
Haemolytic anaemia	isosorbide	LLT	C0002878
Haemolytic anaemia	isosorbide	PT	C0002878
Headache	isosorbide	LLT	C0018681
Headache	isosorbide	PT	C0018681
Hypotension	isosorbide	LLT	C0020649
Hypotension	isosorbide	PT	C0020649
Hypotension	isosorbide	PT	C0020649
Hypotensive	isosorbide	LLT	C0857353
Lightheadedness	isosorbide	LLT	C0220870
Loss of consciousness	isosorbide	PT	C0041657
Methaemoglobinaemia	isosorbide	LLT	C0025637
Methaemoglobinaemia	isosorbide	PT	C0025637
Nausea	isosorbide	LLT	C0027497
Nausea	isosorbide	PT	C0027497
Oedema peripheral	isosorbide	LLT	C0085649
Oedema peripheral	isosorbide	PT	C0085649
Rash	isosorbide	LLT	C0015230
Rash	isosorbide	PT	C0015230
Rebound hypertension	isosorbide	LLT	C0520540
Reflex tachycardia	isosorbide	LLT	C1328539
Shock	isosorbide	PT	C0036974
Syncope	isosorbide	LLT	C0039070
Syncope	isosorbide	PT	C0039070
Tachycardia	isosorbide	PT	C0039231
Vomiting	isosorbide	LLT	C0042963
Vomiting	isosorbide	PT	C0042963
Withdrawal hypertension	isosorbide	PT	C0857468

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Isosorbide used for in pharmaceutical contexts?

Isosorbide (CAS 652-67-5) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Isosorbide?

Isosorbide has 611 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Cardiospasm, Palmoplantar keratoderma, Pruritus genital, Myocardial infarction, Sleep terror. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Isosorbide also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for ISOSORBIDE with EU status "permitted".

What clinical phase is Isosorbide in?

Isosorbide is rendered with ChEMBL max phase 4 (approved).