What is the NOAEL for Naproxen?
Naproxen has 8 NOAEL studies in the database. The lowest reported value is 26.48 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Naproxen
Also known as: EINECS 244-838-7, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-, Napren E (+15 more)
CAS 22204-53-1
Naproxen (CAS 22204-53-1) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Naproxen is classified GHS Danger (H301, H302, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
13
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Naproxen
CAS Number
22204-53-1
DTXSID
DTXSID4040686
Molecular Formula
C14H14O3
InChI Key
CMWTZPSULFXXJA-VIFPVBQESA-N
Monoisotopic Mass
230.094294
Synonyms
EINECS 244-838-7(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-Napren E(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acidFlanax ForteHeadlonNalyxanNapratecNaprontagNaprosyn LLE
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| detected; drinking_water | Illinois EPA | CPCat |
| detected; drinking_water | Illinois EPA | CPCat |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; pharmaceutical; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | National Parks Service | State of Minnesota |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
| detected; MN Chemical Screening; surface_water | NPS & EPA | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 26.48 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 57Y76R9ATQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 57Y76R9ATQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 57Y76R9ATQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 57Y76R9ATQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.002 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =248 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =534 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Naproxen | 244-838-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
NAPROXEN
ChEMBL Phase
4
Adverse Events
2706
Bioactivity
16
Frequently Asked Questions
What regulatory lists include Naproxen?
Naproxen appears on 7 regulatory/inventory lists including pharmaceutical, detected; drinking_water, Europe; pharmaceutical, and 4 more. Source: EPA CPDat.
Is Naproxen used in cosmetics?
Yes, Naproxen is also indexed as a cosmetic ingredient under the name NAPROXEN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Naproxen come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Naproxen have different safety status in cosmetics vs industrial chemicals?
Naproxen is classified GHS Danger (H301, H302, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
Is Naproxen used outside industrial chemicals?
Naproxen also appears in cosmetics, pharmaceutical databases.