Is NAPROXEN safe in cosmetics?
NAPROXEN has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
NAPROXEN
Also known as: EINECS 244-838-7, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-, Napren E (+15 more)
NAPROXEN (CAS 22204-53-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 22204-53-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
NAPROXEN is classified GHS Danger (H301, H302, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
InChIKey
CMWTZPSULFXXJA-VIFPVBQESA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Naproxen is an FDA-approved OTC and prescription drug (NSAID). Including it in a cosmetic product would likely cause the product to be classified as a **drug** under the FD\&C Act, requiring an NDA/ANDA or OTC monograph compliance. Not explicitly prohibited in cosmetics, but functionally restricted by drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Pharmaceutical
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for NAPROXEN.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
EINECS 244-838-7
(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-
Napren E
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
Flanax Forte
Headlon
Nalyxan
Napratec
Naprontag
Naprosyn LLE
Naprosyn LLE Forte
Naproxi 250
Naproxi 500
Narocin
Naxen F
Naxopren
Prafena
Priaxen
Chemical Function
Softener and conditioner
Pharmaceutical
Regulatory Lists
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
detected; drinking_water
detected; drinking_water
Europe; pharmaceutical
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; pharmaceutical; surface_water
detected; drinking_water; MN Chemical Screening
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; surface_water
Canada; pharmaceutical
Frequently Asked Questions
Is NAPROXEN allowed in the EU?
NAPROXEN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NAPROXEN do in cosmetics?
NAPROXEN functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 22204-53-1.
Is NAPROXEN used outside cosmetics?
NAPROXEN also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does NAPROXEN have different safety status in cosmetics vs industrial chemicals?
NAPROXEN is classified GHS Danger (H301, H302, H315, H319, H335, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check NAPROXEN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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