What is the NOAEL for Ethylenediaminetetraacetic acid, disodium salt?
Ethylenediaminetetraacetic acid, disodium salt has 23 NOAEL studies in the database. The lowest reported value is 1.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethylenediaminetetraacetic acid, disodium salt
Also known as: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, CBC 50152966, Cheladrate, Disodium dihydrogen(ethylenedinitrilo)tetraacetate, Disodium edta, anhydrous (+15 more)
CAS 139-33-3
Ethylenediaminetetraacetic acid, disodium salt (CAS 139-33-3) is a chemical substance. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
23
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Ethylenediaminetetraacetic acid, disodium salt
CAS Number
139-33-3
DTXSID
DTXSID9027073
Molecular Formula
C10H16N2O8.2Na
InChI Key
ZGTMUACCHSMWAC-UHFFFAOYSA-L
Monoisotopic Mass
338.070204
Synonyms
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium saltCBC 50152966CheladrateDisodium dihydrogen(ethylenedinitrilo)tetraacetateDisodium edta, anhydrousDisodium ethylenediaminetetraacetic acidDisodium (ethylenedinitrilo)tetraacetic acidDisodium salt of EDTADiso-TateEdetic acid disodium saltEINECS 205-358-3N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Chelating agentViscosity modifierBiocideAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8NLQ36F6MM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8NLQ36F6MM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8NLQ36F6MM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8NLQ36F6MM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~30 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =15 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =3 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=15 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 375 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 954 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =954 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1125 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =1125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1243 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium dihydrogen ethylenediaminetetraacetate | 205-358-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
chelating-agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
EDETATE DISODIUM ANHYDROUS
ChEMBL Phase
4
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E386 — ADI: 2.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethylenediaminetetraacetic acid, disodium salt?
Ethylenediaminetetraacetic acid, disodium salt appears on 9 regulatory/inventory lists including children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bubble bath, Europe; Personal care, and 6 more. Source: EPA CPDat.
Is Ethylenediaminetetraacetic acid, disodium salt used in cosmetics?
Yes, Ethylenediaminetetraacetic acid, disodium salt is also indexed as a cosmetic ingredient under the name Disodium EDTA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethylenediaminetetraacetic acid, disodium salt come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethylenediaminetetraacetic acid, disodium salt used outside industrial chemicals?
Ethylenediaminetetraacetic acid, disodium salt also appears in cosmetics, pharmaceutical, food safety, cannabis databases.