Food Safety Substance
Ethylenediaminetetraacetic acid, disodium saltE386
Ethylenediaminetetraacetic acid, disodium salt (E386) is a food additive with Not currently EU-listed separately in the EU, GRAS in the US, and data from 4 regulatory sources.
CAS 139-33-3
E386
Indexable evidence set
FDA
GRAS
ADI / TDI
ADI 2.5 mg/kg bw
Codex
36 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 4 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
Ethylenediaminetetraacetic acid, disodium salt
CAS
139-33-3
E-number
E386
DTXSID
DTXSID9027073
PubChem CID
8759
Evidence tier
Indexable evidence set (10)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | Not currently EU-listed separately | - |
| Codex | Codex Alimentarius | Listed | Antioxidant; Preservative; Sequestrant |
SOURCE
Codex Alimentarius
Codex GSFA
Codex GSFA Status
Codex Alimentarius GSFA permissions and maximum-use rows.
| Jurisdiction | INS / E-number | Function | Food category | Max level | Notes |
|---|---|---|---|---|---|
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 02.2.2 Fat spreads, dairy fat spreads and blended spreads | 100 mg/kg | Excluding products conforming to the Standard for Dairy Fat Spreads (CXS 253-2006).; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.10 Fermented fruit products | 250 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.11 Fruit fillings for pastries | 650 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.2 Dried fruit | 265 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.3 Fruit in vinegar, oil, or brine | 250 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.5 Jams, jellies, marmelades | 130 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.1.2.6 Fruit-based spreads (e.g. chutney) excluding products of food category 04.1.2.5 | 100 mg/kg | Excluding products conforming to the Standard for Mango Chutney (CODEX STAN 160-1987).; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.1 Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds | 100 mg/kg | For use in French fried potatoes conforming to the Standard for Quick Frozen Vegetables (CXS 320-2015) as a sequestrant.; As anhydrous calcium disodium... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.2 Dried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds | 800 mg/kg | For use in dry beans.; Except for products conforming to the Regional Standard for Laver Products (CXS 323R-2017), only for use in Seasoned Laver Products.; The level in the... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.3 Vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds in vinegar, oil, brine, or soybean sauce | 250 mg/kg | Except for use in products conforming to the Standard for Table Olives (CXS 66-1981): antioxidant and preservative functions are permitted for use in all table olives, while use... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.4 Canned or bottled (pasteurized) or retort pouch vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds | 365 mg/kg | Excluding products conforming to the Codex Regional Standard for Canned Humus with Tehena (CODEX STAN 257R-2007).; Except for use in products conforming to the Regional Standard... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.5 Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed purees and spreads (e.g., peanut butter) | 250 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate.; Excluding products conforming to the Standard for Processed Tomato Concentrates (CODEX STAN 57-1981). [Group: ETHYLENE... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.6 Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed pulps and preparations (e.g. vegetable desserts and sauces, candied vegetables) other than food category 04.2.2.5 | 80 mg/kg | Excluding products conforming to the Regional Standard for Harissa (Red Hot Pepper Paste) (CXS 308R-2011).; Excluding products conforming to the Codex Regional Standard for Tehena... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.7 Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, 12.9.2.1 and 12.9.2.3 | 250 mg/kg | Excluding products conforming to the Standard for Gochujang (CXS 294-2009).; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 04.2.2.8 Cooked or fried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds | 250 mg/kg | Except for products conforming to the Regional Standard for Laver Products (CXS 323R-2017), only for use in Seasoned Laver Products.; As anhydrous calcium disodium... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 05.1.3 Cocoa-based spreads, including fillings | 50 mg/kg | Excluding products conforming to the Standard for Cocoa Butter (CODEX STAN 86-1981).; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 06.5 Cereal and starch based desserts (e.g. rice pudding, tapioca pudding) | 315 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 08.3.2 Heat-treated processed comminuted meat, poultry, and game products | 35 mg/kg | Excluding products conforming to Standard for Luncheon Meat (CODEX STAN 89-1981).; Excluding products conforming to the Standard for Cooked Cured Chopped Meat (CODEX STAN... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 09.2.1 Frozen fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | 75 mg/kg | Excluding products conforming to the Standard for Quick Frozen Blocks of Fish Fillet, Minced Fish Flesh and Mixtures of Fillets and Minced Fish Flesh (CODEX STAN 165-1989).;... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 09.2.2 Frozen battered fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | 75 mg/kg | Excluding products conforming to the Standard for Quick Frozen Fish Sticks (Fish Fingers), Fish Portions and Fish Fillets – Breaded or in Batter (CODEX STAN 166-1989).; As... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 09.2.4.1 Cooked fish and fish products | 50 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 09.3.2 Fish and fish products, including mollusks, crustaceans, and echinoderms, pickled and/or in brine | 250 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 09.4 Fully preserved, including canned or fermented fish and fish products, including mollusks, crustaceans, and echinoderms | 340 mg/kg | Excluding products conforming to the Standard for Canned Sardines and Sardine-Type Products (CODEX STAN 94-1981).; Excluding products conforming to the Standard for Canned Tuna... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 10.2.3 Dried and/or heat coagulated egg products | 200 mg/kg | On the dry egg yolk weight basis.; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 11.6 Table-top sweeteners, including those containing high-intensity sweeteners | 1,000 mg/kg | On the dried weight basis of the high intensity sweetener.; As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 12.2 Herbs, spices, seasonings and condiments (e.g. seasoning for instant noodles) | 70 mg/kg | Excluding products conforming to the Standard for Dried or Dehydrated Chilli Pepper and Paprika (CXS 353-2022).; Excluding products conforming to the Standard for Dried Floral... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 12.4 Mustards | 75 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 12.6.1 Emulsified sauces and dips (e.g. mayonnaise, salad dressing, onion dip) | 100 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 12.6.2 Non-emulsified sauces (e.g. ketchup, cheese sauce, cream sauce, brown gravy) | 75 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate.; Except for use in products conforming to the Standard for Chili Sauce (CXS 306-2011): Disodium... |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 12.7 Salads (e.g. macaroni salad, potato salad) and sandwich spreads excluding cocoa- and nut-based spreads of food categories 04.2.2.5 and 05.1.3 | 100 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 13.6 Food supplements | 150 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 14.1.4 Water-based flavoured drinks, including sport, energy, or electrolyte drinks and particulated drinks | 200 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 14.1.5 Coffee, coffee substitutes, tea, herbal infusions, and other hot cereal and grain beverages, excluding cocoa | 35 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 14.2.1 Beer and malt beverages | 25 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 14.2.6 Distilled spirituous beverages containing more than 15% alcohol | 25 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
| Codex | 386 | Antioxidant; Preservative; Sequestrant | 14.2.7 Aromatized alcoholic beverages (e.g. beer, wine and spirituous cooler-type beverages, low alcoholic refreshers) | 25 mg/kg | As anhydrous calcium disodium ethylenediaminetetraacetate. [Group: ETHYLENE DIAMINE TETRA ACETATES] |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | DISODIUM ETHYLENEDIAMINETETRAACETATE | - | 139-33-3 | 0-2.5 mg/kg bw | 2.5 | ANTIOXIDANT_SYNERGIST, PRESERVATIVE, SEQUESTRANT, SYNERGIST | 1973 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is Ethylenediaminetetraacetic acid, disodium salt used for in food?
Ethylenediaminetetraacetic acid, disodium salt appears in food-use rows as: acidity_regulator; Antioxidant; Preservative; Sequestrant.
Is Ethylenediaminetetraacetic acid, disodium salt / E386 safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI 2.5 mg/kg bw. EU status evidence: Not currently EU-listed separately. US/FDA evidence: GRAS.
What is the ADI for Ethylenediaminetetraacetic acid, disodium salt?
Ethylenediaminetetraacetic acid, disodium salt has this ADI/reference value in the food-safety tables: ADI 2.5 mg/kg bw. Source: food_additives.
Is Ethylenediaminetetraacetic acid, disodium salt also used in cosmetics?
Ethylenediaminetetraacetic acid, disodium salt has a same-CAS cosmetics cross-reference: Disodium EDTA, EU status permitted.