Is Vinyl Guaiacol safe in cosmetics?
Vinyl Guaiacol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Vinyl Guaiacol
Also known as: 3-06-00-04981, BRN 2044521, EINECS 232-101-2, FEMA No. 2675, Vinylcatechol-O-methyl ether, P- (+6 more)
INCI: VINYL GUAIACOL (4-VINYLGUAIACOL / 2-METHOXY-4-VINYLPHENOL)
Vinyl Guaiacol (CAS 7786-61-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; masking agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7786-61-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Vinyl Guaiacol is classified GHS Danger (H314, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient; masking agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-ethenyl-2-methoxyphenol
InChIKey
YOMSJEATGXXYPX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as flavoring agent (FEMA 2675); permitted in cosmetics as fragrance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vinyl Guaiacol.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
725
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHOXY-4-VINYLPHENOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-VINYLGUAIACOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-HYDROXY-3-METHOXYSTYRENE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Vinyl Guaiacol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
3-06-00-04981
BRN 2044521
EINECS 232-101-2
FEMA No. 2675
Vinylcatechol-O-methyl ether, P-
UNII-DA069CTH0O
2-(4-hydroxy-3-methoxyphenyl)ethene
2M4VP
4-hydroxy-3-methoxyphenylethene
4-vinyl-2-methoxyphenol
para-vinylguaiacol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Cleaning products and household care - air freshener; Europe
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
artificial_saliva; detected; emissions; Europe; Toys and children's products
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1232595
Frequently Asked Questions
Is Vinyl Guaiacol allowed in the EU?
Vinyl Guaiacol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vinyl Guaiacol do in cosmetics?
Vinyl Guaiacol functions as: Fragrance ingredient; masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 7786-61-0.
Is Vinyl Guaiacol used outside cosmetics?
Vinyl Guaiacol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Vinyl Guaiacol have different safety status in cosmetics vs industrial chemicals?
Vinyl Guaiacol is classified GHS Danger (H314, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Vinyl Guaiacol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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