Is Valencene safe in cosmetics?
Valencene has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Valencene
Also known as: (+)-Valencene, 4alpha,10alpha-Dimethyl-6beta-isopropyl-delta1,9-octalin, EINECS 225-047-6, 4Betah,5alpha-eremophila-1(10),11-diene, FEMA No. 3443 (+6 more)
INCI: VALENCENE
Valencene (CAS 4630-07-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (sesquiterpene hydrocarbon from citrus). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4630-07-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Valencene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient (sesquiterpene hydrocarbon from citrus)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(3R,4aS,5R)-4a,5-dimethyl-3-prop-1-en-2-yl-2,3,4,5,6,7-hexahydro-1H-naphthalene
InChIKey
QEBNYNLSCGVZOH-NFAWXSAZSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS; permitted in cosmetics and food. No FDA restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Valencene.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
VALENCENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Valencene.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
(+)-Valencene
4alpha,10alpha-Dimethyl-6beta-isopropyl-delta1,9-octalin
EINECS 225-047-6
4Betah,5alpha-eremophila-1(10),11-diene
FEMA No. 3443
Naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, (1R-(1alpha,7beta,8aalpha))-
1,2,3,5,6,7,8,8a-Octahydro-1,8A-dimethyl-7-(1-methylethenyl)naphthalene, (1R-(1alpha,7beta,8aalpha))-
4alpha,10alpha-Dimethyl-6beta-isopropyl-.DELTA.1,9-octalin
UNII-96H21P91IG
(1R-(1alpha,7beta,8alpha))-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene
ent-7betaH-eremophila-10(1),11-diene
Chemical Function
Humectant
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186909
Frequently Asked Questions
Is Valencene allowed in the EU?
Valencene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Valencene do in cosmetics?
Valencene functions as: Fragrance ingredient (sesquiterpene hydrocarbon from citrus). It is classified as a cosmetic ingredient in our database. CAS number: 4630-07-3.
Is Valencene used outside cosmetics?
Valencene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Valencene have different safety status in cosmetics vs industrial chemicals?
Valencene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Valencene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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