Is Urea Peroxide safe in cosmetics?
Urea Peroxide has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Urea Peroxide
Also known as: Urea, compd. with hydrogen peroxide (H2O2) (1:1), EINECS 204-701-4, Hydrogen peroxide, compd. with urea (1:1), Perhydrol-Urea, Carbamide Peroxide Otic Solution (+8 more)
INCI: UREA PEROXIDE
Urea Peroxide (CAS 124-43-6) is a cosmetic cosmetic ingredient functioning as Oral Care Agent (tooth bleaching), Oxidizing Agent. NOAEL 216 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-43-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Urea Peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Oral Care Agent (tooth bleaching), Oxidizing Agent
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in OTC oral care products; tooth-whitening products containing above certain concentration may be regulated as medical devices
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Urea Peroxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Urea Peroxide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Oxidizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Urea Peroxide.
Known Synonyms
Urea, compd. with hydrogen peroxide (H2O2) (1:1)
EINECS 204-701-4
Hydrogen peroxide, compd. with urea (1:1)
Perhydrol-Urea
Carbamide Peroxide Otic Solution
UNII-31PZ2VAU81
Auro Ear Wax Remover
Ear Wax Treatment
Thera-ear
Hydrogen peroxide carbamide
Hydrogen peroxide urea
Urea compound with hydrogen peroxide (1:1)
Urea hydroperoxide
Chemical Function
Oxidizing agent
Catalyst
Regulatory Lists
Canada; pharmaceutical
Europe; Personal care - oral and dental care - teeth whitener
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184026
Adverse Event Associations
111
Frequently Asked Questions
Is Urea Peroxide allowed in the EU?
Urea Peroxide EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Urea Peroxide do in cosmetics?
Urea Peroxide functions as: Oral Care Agent (tooth bleaching), Oxidizing Agent. It is classified as a cosmetic ingredient in our database. CAS number: 124-43-6.
Is Urea Peroxide used outside cosmetics?
Urea Peroxide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Urea Peroxide have different safety status in cosmetics vs industrial chemicals?
Urea Peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Urea Peroxide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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