Is Tromethamine HCl safe in cosmetics?
Tromethamine HCl has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Tromethamine HCl
Also known as: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (1:1) (1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride), EINECS 214-684-5, Tris hydrochloride buffer, UNII-383V75M34E
INCI: TROMETHAMINE HCL
Tromethamine HCl (CAS 1185-53-1) is a cosmetic cosmetic ingredient functioning as pH adjuster, buffering agent (protonated/acidic form of tromethamine). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1185-53-1 →
Auto-generated CPSR Part A draft with source citations
Function
pH adjuster, buffering agent (protonated/acidic form of tromethamine)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
InChIKey
QKNYBSVHEMOAJP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR-reviewed as part of tromethamine group — safe in the practices of use and concentration
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tromethamine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Tromethamine HCl.
Known Synonyms
2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (1:1) (1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride)
EINECS 214-684-5
Tris hydrochloride buffer
UNII-383V75M34E
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183206
Frequently Asked Questions
Is Tromethamine HCl allowed in the EU?
Tromethamine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tromethamine HCl do in cosmetics?
Tromethamine HCl functions as: pH adjuster, buffering agent (protonated/acidic form of tromethamine). It is classified as a cosmetic ingredient in our database. CAS number: 1185-53-1.
Is Tromethamine HCl used outside cosmetics?
Tromethamine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tromethamine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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