What is the NOAEL for Tromethamine hydrochloride?
Tromethamine hydrochloride has 5 NOAEL studies in the database. The lowest reported value is 152.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tromethamine hydrochloride
Also known as: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (1:1) (1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride), EINECS 214-684-5, Tris hydrochloride buffer, Tromethamine HCl, UNII-383V75M34E
CAS 1185-53-1
Tromethamine hydrochloride (CAS 1185-53-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Tromethamine hydrochloride
CAS Number
1185-53-1
DTXSID
DTXSID4044373
Molecular Formula
C4H11NO3.ClH
InChI Key
QKNYBSVHEMOAJP-UHFFFAOYSA-N
Monoisotopic Mass
157.050571
Synonyms
2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (1:1) (1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride)EINECS 214-684-5Tris hydrochloride bufferTromethamine HClUNII-383V75M34E
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =152.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 383V75M34E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 383V75M34E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 383V75M34E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 383V75M34E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride | 214-684-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183206
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is Tromethamine hydrochloride used in cosmetics?
Yes, Tromethamine hydrochloride is also indexed as a cosmetic ingredient under the name Tromethamine HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tromethamine hydrochloride come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Tromethamine hydrochloride used outside industrial chemicals?
Tromethamine hydrochloride also appears in cosmetics, pharmaceutical databases.