Is Tripeptide-29 safe in cosmetics?
Tripeptide-29 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Tripeptide-29
INCI: TRIPEPTIDE-29
Tripeptide-29 (CAS 2239-67-0) is a cosmetic active ingredient functioning as Collagen-mimetic biomimetic peptide that replicates the Gly-Pro-Hyp. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 2239-67-0 →
Auto-generated CPSR Part A draft with source citations
Function
Collagen-mimetic biomimetic peptide that replicates the Gly-Pro-Hyp (glycine-proline-hydroxyproline) tripeptide sequence — the fundamental repeating unit of the collagen triple helix. Provides direct structural reinforcement and stimulates collagen synthesis by presenting a native ECM sequence to fibroblasts. Mechanism differs from signal peptides: Tripeptide-29 mimics the structural building block rather than a matrikine fragment.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. No pre-market approval required under MoCRA for cosmetic peptides.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tripeptide-29.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", "c…
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.1", "typical_concentration_pct": "0.01", "product_type": "Serum", "function_at_concentration": "Collagen synthesis", "source": "Supplier TDS"}
synergy
{"inci_name_2": "Niacinamide", "synergy_type": "efficacy-boost", "synergy_description": "Collagen peptide with barrier vitamin for sensitive anti-aging", "combined_benefit": "Enhanced collagen without irritation, improved barrier function", "efficacy_multiplier": "1.9x", "mechanism_of_action": "Tripeptide-29 stimulates collagen; niacinamide supports barrier reducing sensitivity", "optimal_ratio": …
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Tripeptide-29.
Regulatory Flags
biomimetic-peptide
collagen-mimetic
gly-pro-hyp
structural-reinforcement
Frequently Asked Questions
Is Tripeptide-29 allowed in the EU?
Tripeptide-29 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tripeptide-29 do in cosmetics?
Tripeptide-29 functions as: Collagen-mimetic biomimetic peptide that replicates the Gly-Pro-Hyp (glycine-proline-hydroxyproline) tripeptide sequence — the fundamental repeating unit of the collagen triple helix. Provides direct structural reinforcement and stimulates collagen synthesis by presenting a native ECM sequence to fibroblasts. Mechanism differs from signal peptides: Tripeptide-29 mimics the structural building block rather than a matrikine fragment.. It is classified as a Active Ingredient in our database. CAS number: 2239-67-0.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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