Is Trimethylolpropane Tris-Mercaptopropionate safe in cosmetics?
Trimethylolpropane Tris-Mercaptopropionate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Trimethylolpropane Tris-Mercaptopropionate
Also known as: Propanoic acid, 3-mercapto-, 2-ethyl-2-[(3-mercapto-1-oxopropoxy)methyl]-1,3-propanediyl ester, Propanoic acid, 3-mercapto-, 1,1'-[2-ethyl-2-[(3-mercapto-1-oxopropoxy)methyl]-1,3-propanediyl] ester, 2-Ethyl-2-((3-mercapto-1-oxopropoxy)methyl)propane-1,3-diyl bis(3-mercaptopropionate), Trimethylolpropane tris(3-mercaptopropionate), Epicure QX 30 (+3 more)
INCI: TRIMETHYLOLPROPANE TRIS-MERCAPTOPROPIONATE
Trimethylolpropane Tris-Mercaptopropionate (CAS 33007-83-9) is a cosmetic cosmetic ingredient functioning as Crosslinking agent, reducing agent (primarily industrial; limited direct. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 33007-83-9 →
Auto-generated CPSR Part A draft with source citations
Function
Crosslinking agent, reducing agent (primarily industrial; limited direct cosmetic use)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,2-bis(3-sulfanylpropanoyloxymethyl)butyl 3-sulfanylpropanoate
InChIKey
IMQFZQVZKBIPCQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically addressed for cosmetic use; no FDA prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane Tris-Mercaptopropionate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Hardener
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylolpropane Tris-Mercaptopropionate.
Known Synonyms
Propanoic acid, 3-mercapto-, 2-ethyl-2-[(3-mercapto-1-oxopropoxy)methyl]-1,3-propanediyl ester
Propanoic acid, 3-mercapto-, 1,1'-[2-ethyl-2-[(3-mercapto-1-oxopropoxy)methyl]-1,3-propanediyl] ester
2-Ethyl-2-((3-mercapto-1-oxopropoxy)methyl)propane-1,3-diyl bis(3-mercaptopropionate)
Trimethylolpropane tris(3-mercaptopropionate)
Epicure QX 30
EINECS 251-336-1
3-Mercaptopropanoic acid, 2-ethyl-2-(hydroxymethyl)-1,3-propanediol triester
3-Mercaptopropionic acid triester with trimethylolpropane
Chemical Function
Hardener
Chemical reaction regulator
No specific technical function
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182472
Frequently Asked Questions
Is Trimethylolpropane Tris-Mercaptopropionate allowed in the EU?
Trimethylolpropane Tris-Mercaptopropionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane Tris-Mercaptopropionate do in cosmetics?
Trimethylolpropane Tris-Mercaptopropionate functions as: Crosslinking agent, reducing agent (primarily industrial; limited direct cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 33007-83-9.
Is Trimethylolpropane Tris-Mercaptopropionate used outside cosmetics?
Trimethylolpropane Tris-Mercaptopropionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethylolpropane Tris-Mercaptopropionate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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