Is Trimethylolpropane safe in cosmetics?
Trimethylolpropane has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 3 toxicological study endpoint(s) are available in our database.
Trimethylolpropane
INCI: TRIMETHYLOLPROPANE
Trimethylolpropane (CAS 77-99-6) is a cosmetic cosmetic ingredient functioning as Humectant, Solvent. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 77-99-6 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-ethyl-2-(hydroxymethyl)propane-1,3-diol
InChIKey
ZJCCRDAZUWHFQH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Permitted for cosmetic use; not specifically restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Trimethylolpropane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =450 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =800 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation to the eyes and respiratory tract.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0366
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Heat stabilizer
Humectant
Processing aids not otherwise specified
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylolpropane.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Trimethylolpropane by CAS number or substance name.
Studies
3
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Solvent
Humectant
Heat stabilizer
Regulatory Lists
artificial_saliva; detected; emissions; Europe; Toys and children's products
Europe; plastic_additive
inert_ingredient; non_food_use; Pesticides
CEDI
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185136
Frequently Asked Questions
Is Trimethylolpropane allowed in the EU?
Trimethylolpropane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane do in cosmetics?
Trimethylolpropane functions as: Humectant, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 77-99-6.
What is the NOAEL for Trimethylolpropane?
The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane is =200 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Trimethylolpropane used outside cosmetics?
Trimethylolpropane also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethylolpropane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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