NOAEL Data REACH Registered Cosmetic Ingredient

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol

Also known as: Trimethylolpropane, 4-01-00-02786, BRN 1698309, EINECS 201-074-9, Hexaglycerine (+4 more)

CAS 77-99-6

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol (CAS 77-99-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Trimethylolpropane →

Cross-Vertical Regulatory Divergence

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol is classified GHS Danger (H360) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol

CAS Number

77-99-6

DTXSID

DTXSID2026448

Molecular Formula

C6H14O3

InChI Key

ZJCCRDAZUWHFQH-UHFFFAOYSA-N

Monoisotopic Mass

134.094294

Synonyms

Trimethylolpropane4-01-00-02786BRN 1698309EINECS 201-074-9HexaglycerineHexaglycerolMethanol, (propanetriyl)tris-Tri(hydroxymethyl)propaneUNII-090GDF4HBD

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	May cause mechanical irritation to the eyes and respiratory tract.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 23 records

SolventHumectantHeat stabilizerProcessing aids not otherwise specifiedChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies

Value	Unit	Endpoint	Route	Species	Source
=3.3	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
090GDF4HBD	UNII	FDA UNII substance identifier	-	-	openFDA substances
090GDF4HBD	UNII	FDA UNII substance identifier	-	-	openFDA substances
090GDF4HBD	UNII	FDA UNII substance identifier	-	-	openFDA substances
090GDF4HBD	UNII	FDA UNII substance identifier	-	-	openFDA substances
>=700	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
~1180	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
<=2000	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
~7000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
~19.2072	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
~130	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=450	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
=740	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=800	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2200	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~3000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>6000	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=6600	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=100	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 20 of 20 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Propylidynetrimethanol	201-074-9	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3185136

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol?

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol has 20 NOAEL studies in the database. The lowest reported value is 3.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol?

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol appears on 6 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Toys and children's products, Europe; plastic_additive, inert_ingredient; non_food_use; Pesticides, and 3 more. Source: EPA CPDat.

Is 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol used in cosmetics?

Yes, 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol is also indexed as a cosmetic ingredient under the name Trimethylolpropane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol have different safety status in cosmetics vs industrial chemicals?

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol is classified GHS Danger (H360) in the chemicals database but is allowed in EU cosmetics.

Is 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol used outside industrial chemicals?

2-Ethyl-2-(hydroxymethyl)-1,3-propanediol also appears in cosmetics, pharmaceutical databases.