Is Trimethylbenzenepropanol safe in cosmetics?
Trimethylbenzenepropanol has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Trimethylbenzenepropanol
Also known as: UNII-7S411YY2VY
INCI: TRIMETHYLBENZENEPROPANOL
Trimethylbenzenepropanol (CAS 103694-68-4) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 103694-68-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,2-dimethyl-3-(3-methylphenyl)propan-1-ol
InChIKey
FYMOBFDUZIDKMI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted as a fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylbenzenepropanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Trimethylbenzenepropanol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Pictograms
?
Hazard Class and Category
Aquatic Chronic 3
Hazard Statements
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
1.6%
DPRA Lys %
2.5%
KeratinoSens IC50
629.315 µM
hCLAT CV75
186 µg/mL
LLNA EC3
100%
NESIL
5510 µg/cm²
LLNA: NC (non-sensitizer)
GHS: not classified
Human: positive
Source: LLNA: Report to RIFM from Symrise (RIFM DB #58693) | Report to RIFM from Symrise (RIFM DB #60266); DPRA: Hoffmann et al., 2018 | Unilever commissioned, Charles River; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database; HPPT: [80] RIFM (2005): RIFM report number 49526, September 12, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 5510 | - | - |
| HRIPT | - | 0 | 9920 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylbenzenepropanol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
UNII-7S411YY2VY
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Trimethylbenzenepropanol allowed in the EU?
Trimethylbenzenepropanol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylbenzenepropanol do in cosmetics?
Trimethylbenzenepropanol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 103694-68-4.
Is Trimethylbenzenepropanol used outside cosmetics?
Trimethylbenzenepropanol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethylbenzenepropanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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