Is Tricalcium Phosphate safe in cosmetics?
Tricalcium Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Tricalcium Phosphate
Also known as: Calcium orthophosphate, tri-(tert), Caswell No. 148, EINECS 231-840-8, EPA Pesticide Chemical Code 076401, FEMA No. 3081 (+9 more)
INCI: TRICALCIUM PHOSPHATE
Tricalcium Phosphate (CAS 7758-87-4) is a cosmetic cosmetic ingredient functioning as Opacifier, abrasive, anti-caking agent, oral care/remineralization agent,. NOAEL 6.67 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7758-87-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tricalcium Phosphate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Opacifier, abrasive, anti-caking agent, oral care/remineralization agent, bulking agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
tricalcium diphosphate
InChIKey
QORWJWZARLRLPR-UHFFFAOYSA-H
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; GRAS food additive (21 CFR 182); USP grade available
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tricalcium Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tricalcium Phosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
oral_care
{"cas_number": "7758-87-4", "ingredient_class": "remineralizing", "function_primary": "Remineralizing agent", "function_secondary": "Abrasive (mild)", "anti_caries_mechanism": "Provides calcium and phosphate ions for remineralization", "fluoride_content_ppm_if_applicable": "0", "remineralization_capacity": "Moderate", "enamel_hardness_improvement": "10-15%", "dentin_tubule_occlusion": "Low to mode…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
TRICALCIUM PHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Anti-caking agent
Deodorizer
Drier
Emulsifier
Filler
Flavouring and nutrient
Fragrance
Humectant
Leavening agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tricalcium Phosphate.
Regulatory Flags
fda_food_additive
Known Synonyms
Calcium orthophosphate, tri-(tert)
Caswell No. 148
EINECS 231-840-8
EPA Pesticide Chemical Code 076401
FEMA No. 3081
Natural whitlockite
UNII-K4C08XP666
JAX TCP
Ca3(PO4)2
Calcigenol Simple
Calcium phosphate tribasic
calcium phosphate
tricalcium diphosphate
tricalcium bis(phosphate)
Chemical Function
Abrasive
Deodorizer
Opacifer
Anti-caking agent
Fragrance
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
animal_products
animal_products
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM PHOSPHATE, TRIBASIC
ChEMBL ID
CHEMBL2106566
Max Phase
3
Adverse Event Associations
15
Frequently Asked Questions
Is Tricalcium Phosphate allowed in the EU?
Tricalcium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tricalcium Phosphate do in cosmetics?
Tricalcium Phosphate functions as: Opacifier, abrasive, anti-caking agent, oral care/remineralization agent, bulking agent. It is classified as a cosmetic ingredient in our database. CAS number: 7758-87-4.
Is Tricalcium Phosphate used outside cosmetics?
Tricalcium Phosphate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tricalcium Phosphate have different safety status in cosmetics vs industrial chemicals?
Tricalcium Phosphate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tricalcium Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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