Is Tributyl Citrate safe in cosmetics?
Tributyl Citrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Tributyl Citrate
Also known as: BRN 1806072, n-Butyl citrate, EINECS 201-071-2, Tributyl 2-hydroxy-1,2,3-propanetricarboxylate, UNII-827D5B1B6S
INCI: TRIBUTYL CITRATE
Tributyl Citrate (CAS 77-94-1) is a cosmetic cosmetic ingredient functioning as Film-forming, plasticizer, solvent, hair conditioning, stabilizing. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 77-94-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tributyl Citrate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film-forming, plasticizer, solvent, hair conditioning, stabilizing
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
tributyl 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; GRAS as indirect food additive; CIR assessed safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tributyl Citrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tributyl Citrate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "10-11", "co_emulsifier_pairs": "polysorbate_80,ceteth_20", "optimal_oil_phase_pct": "10-28", "optimal_water_phase_pct": "72-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Plasticizer
Processing aids not otherwise specified
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Tributyl Citrate.
Known Synonyms
BRN 1806072
n-Butyl citrate
EINECS 201-071-2
Tributyl 2-hydroxy-1,2,3-propanetricarboxylate
UNII-827D5B1B6S
Chemical Function
Solvent
Film former
Plasticizer
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Europe; plastic_additive
Arts and crafts/Office supplies - fabric treatment and dye; detected
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRIBUTYL CITRATE
ChEMBL ID
CHEMBL2107619
Max Phase
-1
Frequently Asked Questions
Is Tributyl Citrate allowed in the EU?
Tributyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tributyl Citrate do in cosmetics?
Tributyl Citrate functions as: Film-forming, plasticizer, solvent, hair conditioning, stabilizing. It is classified as a cosmetic ingredient in our database. CAS number: 77-94-1.
Is Tributyl Citrate used outside cosmetics?
Tributyl Citrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tributyl Citrate have different safety status in cosmetics vs industrial chemicals?
Tributyl Citrate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tributyl Citrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Same category
Hair conditioning; modified aminosili...
Acetamidoamodimethicone
Excellent
Same category
Hair conditioning agent (film-forming...
Glyceryl Dioleate/Linoleate/Linolenate
Excellent
Same category
Hair conditioning agent
Gondoic Acid
Excellent
Same category
Hair conditioning
Hydroxypropyldimethicone
Excellent
Same category
Skin/hair conditioning (silicone poly...
Hydroxypropyltrimonium Inulin
Excellent
Same category
Antistatic, hair conditioning
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Similar safety
Fragrance / Perfuming agent with flor...
Acetyl Tributyl Citrate
Good
Chemical family
Plasticizer; solvent; film-former
Acetyl Triethyl Citrate
Excellent
Chemical family
Film Forming, Plasticiser, Masking, P...
Beta-Santalol
Moderate
Chemical family
Fragrance
Is Tributyl Citrate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tributyl Citrate in your formulation.