What is the NOAEL for Tributyl citrate?
Tributyl citrate has 5 NOAEL studies in the database. The lowest reported value is 73.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tributyl citrate
Also known as: BRN 1806072, n-Butyl citrate, EINECS 201-071-2, Tributyl 2-hydroxy-1,2,3-propanetricarboxylate, UNII-827D5B1B6S
CAS 77-94-1
Tributyl citrate (CAS 77-94-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Tributyl citrate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Tributyl citrate
CAS Number
77-94-1
DTXSID
DTXSID5051442
Molecular Formula
C18H32O7
InChI Key
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N
Monoisotopic Mass
360.214803
Synonyms
BRN 1806072n-Butyl citrateEINECS 201-071-2Tributyl 2-hydroxy-1,2,3-propanetricarboxylateUNII-827D5B1B6S
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
54 records
SolventFilm formerPlasticizerProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =73.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 827D5B1B6S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 827D5B1B6S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 827D5B1B6S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 827D5B1B6S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tributyl citrate | 201-071-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Hair Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TRIBUTYL CITRATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Tributyl citrate?
Tributyl citrate appears on 4 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), Europe; plastic_additive, and 1 more. Source: EPA CPDat.
Is Tributyl citrate used in cosmetics?
Yes, Tributyl citrate is also indexed as a cosmetic ingredient under the name Tributyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tributyl citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Tributyl citrate have different safety status in cosmetics vs industrial chemicals?
Tributyl citrate is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Tributyl citrate used outside industrial chemicals?
Tributyl citrate also appears in cosmetics, pharmaceutical databases.