Is Trehalose safe in cosmetics?
Trehalose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Humectant
Trehalose
Also known as: Cabaletta, O-D-Glucopyranosyl-(1→1)-D-glucopyranoside, Thealoz, Treha, Trehalose 100PH (+13 more)
INCI: TREHALOSE
Trehalose (CAS 99-20-7) is a cosmetic humectant functioning as humectant, skin-conditioning, autophagy-inducer. NOAEL 5000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 99-20-7 →
Auto-generated CPSR Part A draft with source citations
Function
humectant, skin-conditioning, autophagy-inducer
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS GRN 000045 (Hayashibara International, 2000) and GRN 912 confirm safety for food use. No pre-market approval required for cosmetic use. GRAS food status supports topical safety profile.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trehalose.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Trehalose across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "99-20-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "hydration-plumping, antioxidant-protection", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_j…
anti_pollution
{"cas_number": "99-20-7", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5/urban_dust/oxidative_stress", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulati…
baby_pediatric
{"cas_number": "99-20-7/6138-23-4", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Disaccharide, protectant", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "H…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone", "acne_safe": "yes", "source": "Humectant"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "25", "estimated_cost_per_kg_usd_high": "45", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Japan/China", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Glycerin, …
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "very low toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "palm_…
hair_care
{"hair_function": "moisturizing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "moisture", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "ker…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Trehalose.
Regulatory Flags
humectant
cir-safe
fda-gras
jecfa-approved
non-sensitizer
non-genotoxic
eu-permitted
negligible-absorption
jecfa_safe
Known Synonyms
Cabaletta
O-D-Glucopyranosyl-(1→1)-D-glucopyranoside
Thealoz
Treha
Trehalose 100PH
Trehaose
.alpha.-D-Glucopyranoside, .alpha.-D-glucopyranosyl
alpha-D-Glucopyranoside, alpha-D-glucopyranosyl
EINECS 202-739-6
UNII-B8WCK70T7I
(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxane-3,4,5-triol
(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol
(2R,3R,4S,5R,6R)-2-methylol-6-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-3,4,5-triol
(Glc)2
D-Trehalose-anhydrous
alpha,alpha-Trehalose
alpha-D-Glcp-(1<->1)-alpha-D-Glcp
Chemical Function
Humectant
Flavouring and nutrient
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TREHALOSE
ChEMBL ID
CHEMBL1236395
Max Phase
3
Adverse Event Associations
1
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Trehalose
ADI
NOT SPECIFIED mg/kg bw
FDA GRAS
FDA has no questions
GRN
45
Food Category
preservative
Use in foods in general, including meat products, for multiple technical effects at levels in accordance with good manufacturing practice
View full food safety profile →Frequently Asked Questions
Is Trehalose allowed in the EU?
Trehalose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trehalose do in cosmetics?
Trehalose functions as: humectant, skin-conditioning, autophagy-inducer. It is classified as a Humectant in our database. CAS number: 99-20-7.
Is Trehalose used outside cosmetics?
Trehalose also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trehalose compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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