Is Tioxolone safe in cosmetics?
Tioxolone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tioxolone
Also known as: EINECS 225-653-0, Tioxolona, Tioxolonum, UNII-S0FAJ1R9CD, 6-Hydro-2-oxo-1,3-benzoxathiole (+3 more)
INCI: TIOXOLONE
Tioxolone (CAS 4991-65-5) is a cosmetic cosmetic ingredient functioning as Astringent, sebostatic (anti-sebum), antibacterial — used in acne and oily skin. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4991-65-5 →
Auto-generated CPSR Part A draft with source citations
Function
Astringent, sebostatic (anti-sebum), antibacterial — used in acne and oily skin products
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
6-hydroxy-1,3-benzoxathiol-2-one
InChIKey
SLYPOVJCSQHITR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Previously marketed as OTC acne ingredient; FDA monograph history; permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tioxolone.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Astringent
Expert Verdict
Expert safety assessment and concern-level summary for Tioxolone.
Known Synonyms
EINECS 225-653-0
Tioxolona
Tioxolonum
UNII-S0FAJ1R9CD
6-Hydro-2-oxo-1,3-benzoxathiole
6-Hydroxy-1,3-benzoxathiol-2-one
Thioxalone
Tioxolon
Chemical Function
Astringent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TIOXOLONE
ChEMBL ID
CHEMBL442687
Max Phase
2
Frequently Asked Questions
Is Tioxolone allowed in the EU?
Tioxolone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tioxolone do in cosmetics?
Tioxolone functions as: Astringent, sebostatic (anti-sebum), antibacterial — used in acne and oily skin products. It is classified as a cosmetic ingredient in our database. CAS number: 4991-65-5.
Is Tioxolone used outside cosmetics?
Tioxolone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tioxolone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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