What is the NOAEL for Thioxolone?
Thioxolone has 6 NOAEL studies in the database. The lowest reported value is S0FAJ1R9CD UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Thioxolone
Also known as: EINECS 225-653-0, Tioxolona, Tioxolonum, UNII-S0FAJ1R9CD, 6-Hydro-2-oxo-1,3-benzoxathiole (+4 more)
CAS 4991-65-5
Thioxolone (CAS 4991-65-5) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Thioxolone
CAS Number
4991-65-5
DTXSID
DTXSID5045885
Molecular Formula
C7H4O3S
InChI Key
SLYPOVJCSQHITR-UHFFFAOYSA-N
Monoisotopic Mass
167.988115
Synonyms
EINECS 225-653-0TioxolonaTioxolonumUNII-S0FAJ1R9CD6-Hydro-2-oxo-1,3-benzoxathiole6-Hydroxy-1,3-benzoxathiol-2-oneThioxaloneTioxolontioxolone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Astringent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| S0FAJ1R9CD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S0FAJ1R9CD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S0FAJ1R9CD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S0FAJ1R9CD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3.71 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =633 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TIOXOLONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Thioxolone?
Thioxolone appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Thioxolone used in cosmetics?
Yes, Thioxolone is also indexed as a cosmetic ingredient under the name Tioxolone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Thioxolone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Thioxolone used outside industrial chemicals?
Thioxolone also appears in cosmetics, pharmaceutical databases.