Is Tetrapeptide-21 safe in cosmetics?
Tetrapeptide-21 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Active Ingredient
Tetrapeptide-21
INCI: TETRAPEPTIDE-21
Tetrapeptide-21 (CAS None) is a cosmetic active ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS None →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrapeptide-21.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", "c…
anti_pollution
{"cas_number": "223749-130-7", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhib…
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.1", "typical_concentration_pct": "0.01", "product_type": "Serum", "function_at_concentration": "Skin barrier, hydration", "source": "Supplier TDS"}
synergy
{"inci_name_2": "Vitamin C", "synergy_type": "efficacy-boost", "synergy_description": "Collagen peptide with vitamin C for maximum synthesis", "combined_benefit": "Superior collagen production, enhanced firmness, brightening benefits", "efficacy_multiplier": "2.5x", "mechanism_of_action": "Peptide signals collagen; vitamin C is essential hydroxylation cofactor", "optimal_ratio": "1:15 (1% peptide …
Expert Verdict
Expert safety assessment and concern-level summary for Tetrapeptide-21.
Frequently Asked Questions
Is Tetrapeptide-21 allowed in the EU?
Tetrapeptide-21 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrapeptide-21 do in cosmetics?
Tetrapeptide-21 functions as: Skin Conditioning. It is classified as a Active Ingredient in our database. CAS number: None.
Compliance Tools
Check Tetrapeptide-21 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Perfuming
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