Is Tetramethylpyrazine safe in cosmetics?
Tetramethylpyrazine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tetramethylpyrazine
Also known as: 2,3,5,6-Tetramethylpyrazine, EINECS 214-391-2, FEMA No. 3237, 2,3,5,6-Tetramethyl pyrazine, Tetramethylpyrazin (+2 more)
INCI: TETRAMETHYLPYRAZINE (2,3,5,6-TETRAMETHYLPYRAZINE; ALSO KNOWN AS LIGUSTRAZINE)
Tetramethylpyrazine (CAS 1124-11-4) is a cosmetic cosmetic ingredient functioning as Fragrance — enhances and perfumes the product; also recognized for vasodilatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1124-11-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance — enhances and perfumes the product; also recognized for vasodilatory and anti-inflammatory properties in traditional medicine
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,3,5,6-tetramethylpyrazine
InChIKey
FINHMKGKINIASC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS (Generally Recognized as Safe) as a food flavoring agent; permitted in cosmetics as fragrance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethylpyrazine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
780
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,3,5,6-TETRAMETHYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethylpyrazine.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2,3,5,6-Tetramethylpyrazine
EINECS 214-391-2
FEMA No. 3237
2,3,5,6-Tetramethyl pyrazine
Tetramethylpyrazin
UNII-V80F4IA5XG
Liqustrazine
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LIGUSTRAZINE
ChEMBL ID
CHEMBL303697
Frequently Asked Questions
Is Tetramethylpyrazine allowed in the EU?
Tetramethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethylpyrazine do in cosmetics?
Tetramethylpyrazine functions as: Fragrance — enhances and perfumes the product; also recognized for vasodilatory and anti-inflammatory properties in traditional medicine. It is classified as a cosmetic ingredient in our database. CAS number: 1124-11-4.
Is Tetramethylpyrazine used outside cosmetics?
Tetramethylpyrazine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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