Is Tetramethyl Decynediol safe in cosmetics?
Tetramethyl Decynediol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Tetramethyl Decynediol
Also known as: 2,4,7,9-Tetramethyl-5-decyne-4,7-diol, 5-Decyne-4,7-diol, 2,4,7,9-tetramethyl-, 2,4,7,9-Tetramethyl-5-decyn-4,7-diol, Acetylenol E 00, Olfine AK 02 (+15 more)
INCI: TETRAMETHYL DECYNEDIOL
Tetramethyl Decynediol (CAS 126-86-3) is a cosmetic cosmetic ingredient functioning as Surfactant — cleansing; defoamer, wetting agent. Reported NOAEL =240 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 126-86-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetramethyl Decynediol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H318, H319, H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Surfactant — cleansing; defoamer, wetting agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,4,7,9-tetramethyldec-5-yne-4,7-diol
InChIKey
LXOFYPKXCSULTL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically regulated for cosmetics; primarily industrial use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethyl Decynediol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Tetramethyl Decynediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =240 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Dog | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Defoamer
No specific technical function
Surfactant (surface active agent)
Wetting agent (non-aqueous)
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethyl Decynediol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetramethyl Decynediol by CAS number or substance name.
Studies
2
Lowest NOAEL
240 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,4,7,9-Tetramethyl-5-decyne-4,7-diol
5-Decyne-4,7-diol, 2,4,7,9-tetramethyl-
2,4,7,9-Tetramethyl-5-decyn-4,7-diol
Acetylenol E 00
Olfine AK 02
Olfine PD 301
Olfine STG-E
Surfadol 541
Surfynol 104BC
Surfynol 104H
Surfynol 104PA
Surfynol CT 111
Surfynol PG 50
Surfynol TG
Zetasperse 1200
DEC-5-YNE-4,7-DIOL, 2,4,7,9-TETRAMETHYL-
5,DECYNE-4,7-DIOL, 2,4,7,9-TETRAMETHYL-
5-Decino-4 ,7-diol, 2,4,7,9-tetrametil -
2,4,7,9-tetrametildec-5-ino-4,7-diol
Olfine PD 001
Chemical Function
Surfactant (surface active agent)
Cleaning agent
No specific technical function
Defoamer
Regulatory Lists
Indirect additives food contact (10/2018)
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2143891
Frequently Asked Questions
Is Tetramethyl Decynediol allowed in the EU?
Tetramethyl Decynediol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethyl Decynediol do in cosmetics?
Tetramethyl Decynediol functions as: Surfactant — cleansing; defoamer, wetting agent. It is classified as a cosmetic ingredient in our database. CAS number: 126-86-3.
What is the NOAEL for Tetramethyl Decynediol?
The NOAEL (No Observed Adverse Effect Level) for Tetramethyl Decynediol is =240 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Tetramethyl Decynediol used outside cosmetics?
Tetramethyl Decynediol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetramethyl Decynediol have different safety status in cosmetics vs industrial chemicals?
Tetramethyl Decynediol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H318, H319, H412).
Compliance Tools
Check Tetramethyl Decynediol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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