What is the NOAEL for 2,4,7,9-Tetramethyl-5-decyne-4,7-diol?
2,4,7,9-Tetramethyl-5-decyne-4,7-diol has 15 NOAEL studies in the database. The lowest reported value is 1.76 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,4,7,9-Tetramethyl-5-decyne-4,7-diol
Also known as: 5-Decyne-4,7-diol, 2,4,7,9-tetramethyl-, 2,4,7,9-Tetramethyl-5-decyn-4,7-diol, Acetylenol E 00, Olfine AK 02, Olfine PD 301 (+14 more)
CAS 126-86-3
2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS 126-86-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,4,7,9-Tetramethyl-5-decyne-4,7-diol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H318, H319, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
2,4,7,9-Tetramethyl-5-decyne-4,7-diol
CAS Number
126-86-3
DTXSID
DTXSID7027041
Molecular Formula
C14H26O2
InChI Key
LXOFYPKXCSULTL-UHFFFAOYSA-N
Monoisotopic Mass
226.19328
Synonyms
5-Decyne-4,7-diol, 2,4,7,9-tetramethyl-2,4,7,9-Tetramethyl-5-decyn-4,7-diolAcetylenol E 00Olfine AK 02Olfine PD 301Olfine STG-ESurfadol 541Surfynol 104BCSurfynol 104HSurfynol 104PASurfynol CT 111Surfynol PG 50
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
42 records
Surfactant (surface active agent)Cleaning agentNo specific technical functionDefoamerWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.76 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| B9Y126NY8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B9Y126NY8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B9Y126NY8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B9Y126NY8K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =200 | mg/kg bw/day | LOAEL | oral | Dog | ToxValDB_HPVIS |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =240 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2500 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =7500 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =15000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,4,7,9-tetramethyldec-5-yne-4,7-diol | 204-809-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2143891
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2,4,7,9-Tetramethyl-5-decyne-4,7-diol?
2,4,7,9-Tetramethyl-5-decyne-4,7-diol appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is 2,4,7,9-Tetramethyl-5-decyne-4,7-diol used in cosmetics?
Yes, 2,4,7,9-Tetramethyl-5-decyne-4,7-diol is also indexed as a cosmetic ingredient under the name Tetramethyl Decynediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,4,7,9-Tetramethyl-5-decyne-4,7-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,4,7,9-Tetramethyl-5-decyne-4,7-diol have different safety status in cosmetics vs industrial chemicals?
2,4,7,9-Tetramethyl-5-decyne-4,7-diol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H318, H319, H412).
Is 2,4,7,9-Tetramethyl-5-decyne-4,7-diol used outside industrial chemicals?
2,4,7,9-Tetramethyl-5-decyne-4,7-diol also appears in cosmetics, pharmaceutical databases.