Is Tetrahydrolinalool safe in cosmetics?
Tetrahydrolinalool has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Tetrahydrolinalool
Also known as: 2,6-Dimethyl-6-octanol, 3-Octanol, 3,7-dimethyl-, EINECS 201-133-9, EINECS 260-912-1, FEMA No. 3060 (+4 more)
INCI: TETRAHYDROLINALOOL
Tetrahydrolinalool (CAS 78-69-3) is a cosmetic cosmetic ingredient functioning as Fragrance Ingredient (floral, fresh, citrus profile). NOAEL 160 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 78-69-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance Ingredient (floral, fresh, citrus profile)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,7-dimethyloctan-3-ol
InChIKey
DLHQZZUEERVIGQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
GRAS as flavoring agent (21 CFR 172.515; FEMA 3060); permitted in cosmetics as fragrance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydrolinalool.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydrolinalool across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (2)
JECFA Number
357
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TETRAHYDROLINALOOL | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/79 | FAS 42-JECFA 51/293
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahydrolinalool.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2,6-Dimethyl-6-octanol
3-Octanol, 3,7-dimethyl-
EINECS 201-133-9
EINECS 260-912-1
FEMA No. 3060
Linalool tetrahydride
NSC 128151
UNII-UM4XS5M134
Tetrahydromuguol
Chemical Function
Fragrance
Regulatory Lists
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior - auto air freshener
Europe
air; detected; emissions; Personal care
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183871
Frequently Asked Questions
Is Tetrahydrolinalool allowed in the EU?
Tetrahydrolinalool EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydrolinalool do in cosmetics?
Tetrahydrolinalool functions as: Fragrance Ingredient (floral, fresh, citrus profile). It is classified as a cosmetic ingredient in our database. CAS number: 78-69-3.
Is Tetrahydrolinalool used outside cosmetics?
Tetrahydrolinalool also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetrahydrolinalool compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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