Also known as: EINECS 239-360-0, UNII-3KM1212J0Y
INCI: ACETYL HEXAMETHYL INDAN
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) (CAS 15323-35-0) is a cosmetic cosmetic ingredient functioning as Fragrance – polycyclic musk, sweet musky note. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 15323-35-0 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®).
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) across SCCS product categories, with measured dermal absorption where available.
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Expert safety assessment and concern-level summary for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®).
Public NOAEL study rows linked to Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) by CAS number or substance name.
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) functions as: Fragrance – polycyclic musk, sweet musky note. It is classified as a cosmetic ingredient in our database. CAS number: 15323-35-0.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) is =5 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Check Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) compliance across multiple jurisdictions:
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