Is TAED (Tetraacetylethylenediamine) safe in cosmetics?
TAED (Tetraacetylethylenediamine) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
TAED (Tetraacetylethylenediamine)
Also known as: Acetamide, N,N'-1,2-ethanediylbis[N-acetyl-, N,N'-Ethylenebis(N-acetylacetamide), EINECS 234-123-8, UNII-P411ED0N2B
INCI: TAED
TAED (Tetraacetylethylenediamine) (CAS 10543-57-4) is a cosmetic cosmetic ingredient functioning as Bleaching agent (hair/skin lightening); oxygen bleach activator. NOAEL 25 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 10543-57-4 →
Auto-generated CPSR Part A draft with source citations
Function
Bleaching agent (hair/skin lightening); oxygen bleach activator
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-acetyl-N-[2-(diacetylamino)ethyl]acetamide
InChIKey
BGRWYDHXPHLNKA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; primarily used in detergent applications; no specific FDA monograph for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for TAED (Tetraacetylethylenediamine).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for TAED (Tetraacetylethylenediamine). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =90 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for TAED (Tetraacetylethylenediamine) across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Chemical reaction regulator
Oxidizing agent
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for TAED (Tetraacetylethylenediamine).
Regulatory Flags
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TAED (Tetraacetylethylenediamine) by CAS number or substance name.
Studies
2
Lowest NOAEL
90 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetamide, N,N'-1,2-ethanediylbis[N-acetyl-
N,N'-Ethylenebis(N-acetylacetamide)
EINECS 234-123-8
UNII-P411ED0N2B
Chemical Function
Bleaching agent
Oxidizing agent
Regulatory Lists
active_ingredient; Europe; Pesticides
CEDI
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is TAED (Tetraacetylethylenediamine) allowed in the EU?
TAED (Tetraacetylethylenediamine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TAED (Tetraacetylethylenediamine) do in cosmetics?
TAED (Tetraacetylethylenediamine) functions as: Bleaching agent (hair/skin lightening); oxygen bleach activator. It is classified as a cosmetic ingredient in our database. CAS number: 10543-57-4.
What is the NOAEL for TAED (Tetraacetylethylenediamine)?
The NOAEL (No Observed Adverse Effect Level) for TAED (Tetraacetylethylenediamine) is =90 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is TAED (Tetraacetylethylenediamine) used outside cosmetics?
TAED (Tetraacetylethylenediamine) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check TAED (Tetraacetylethylenediamine) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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