What is the NOAEL for Tetraacetylethylenediamine?
Tetraacetylethylenediamine has 25 NOAEL studies in the database. The lowest reported value is 6.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetraacetylethylenediamine
Also known as: Acetamide, N,N'-1,2-ethanediylbis[N-acetyl-, N,N'-Ethylenebis(N-acetylacetamide), EINECS 234-123-8, UNII-P411ED0N2B
CAS 10543-57-4
Tetraacetylethylenediamine (CAS 10543-57-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for TAED (Tetraacetylethylenediamine) →
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Tetraacetylethylenediamine
CAS Number
10543-57-4
DTXSID
DTXSID5040752
Molecular Formula
C10H16N2O4
InChI Key
BGRWYDHXPHLNKA-UHFFFAOYSA-N
Monoisotopic Mass
228.111007
Synonyms
Acetamide, N,N'-1,2-ethanediylbis[N-acetyl-N,N'-Ethylenebis(N-acetylacetamide)EINECS 234-123-8UNII-P411ED0N2B
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Bleaching agentOxidizing agentChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| P411ED0N2B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P411ED0N2B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P411ED0N2B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P411ED0N2B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =7940 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =500 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2000 | mg/kg bw/day | LEL | dermal | rat (sprague dawley; Sprague Dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| 200 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 200 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 1000 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 1000 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| =2000 | mg/kg bw/day | LOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| >- | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =25 | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =200 | mg/kg bw/day | NEL | dermal | rat (sprague dawley; Sprague Dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >=99.7 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=283 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =90 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=25 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N,N'-ethylenebis[N-acetylacetamide] | 234-123-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include Tetraacetylethylenediamine?
Tetraacetylethylenediamine appears on 3 regulatory/inventory lists including active_ingredient; Europe; Pesticides, CEDI, SCIL (9/2019). Source: EPA CPDat.
Is Tetraacetylethylenediamine used in cosmetics?
Yes, Tetraacetylethylenediamine is also indexed as a cosmetic ingredient under the name TAED (Tetraacetylethylenediamine). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetraacetylethylenediamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Tetraacetylethylenediamine used outside industrial chemicals?
Tetraacetylethylenediamine also appears in cosmetics databases.