Is Syn-Coll (Palmitoyl Tripeptide-5) safe in cosmetics?
Syn-Coll (Palmitoyl Tripeptide-5) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Syn-Coll (Palmitoyl Tripeptide-5)
INCI: PALMITOYL TRIPEPTIDE-5
Syn-Coll (Palmitoyl Tripeptide-5) (CAS None) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS None →
Auto-generated CPSR Part A draft with source citations
Function
Peptide / Anti-aging active
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel Safety Assessment of Palmitoyl Oligopeptides as Used in Cosmetics - Scientific Literature Review, Cosmetic Ingredient Review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Syn-Coll (Palmitoyl Tripeptide-5).
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "collagen-boosting, firming", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "15-25", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "623172-56-5", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
depigmentation
{"cas_number": "623172-56-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Collagen-stimulating peptide with brightening effects", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "…
peptide
{"cas_number": "623172-56-5", "trade_name": "Syn-Coll", "peptide_sequence_amino_acids": "Pal-Lys-Val-Lys", "peptide_length_residues": "3", "molecular_weight_daltons": "585.8", "peptide_class": "signal", "mechanism_of_action": "Stimulates TGF-beta, collagen synthesis, inhibits MMPs", "target_protein_or_receptor": "TGF-beta receptor", "biomimetic_of": "collagen_fragment", "collagen_stimulation_type"…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Collagen synthesis peptide", "formulation_note": "Requires neutral pH", "source": "Formulation literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "acceptable", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "collagen-boosti…
synergy
{"inci_name_2": "Ceramide NP", "synergy_type": "efficacy-boost", "synergy_description": "Dermal collagen peptide with barrier lipid for dual-layer benefits", "combined_benefit": "Dermal firmness with epidermal barrier protection, comprehensive anti-aging", "efficacy_multiplier": "1.9x", "mechanism_of_action": "Tripeptide-5 stimulates TGF-β for collagen; ceramides restore barrier structure", "optim…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv":…
Expert Verdict
Expert safety assessment and concern-level summary for Syn-Coll (Palmitoyl Tripeptide-5).
Frequently Asked Questions
Is Syn-Coll (Palmitoyl Tripeptide-5) allowed in the EU?
Syn-Coll (Palmitoyl Tripeptide-5) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Syn-Coll (Palmitoyl Tripeptide-5) do in cosmetics?
Syn-Coll (Palmitoyl Tripeptide-5) functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: None.
Compliance Tools
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MoS Calculator
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