Is Sucrose Acetate Isobutyrate safe in cosmetics?
Sucrose Acetate Isobutyrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Sucrose Acetate Isobutyrate
Also known as: Isobutyric acid, hexaester with sucrose diacetate, Sucrose, diacetate hexaisobutyrate, Sucrose acetate isobutanoate, (2R,3R,4S,5R,6R)-2-((Acetyloxy)methyl)-6-(((2S,3S,4R,5R)-5-((acetyloxy)methyl)-3,4-bis((2-methylpropanoyl)oxy)-2-(((2-methylpropanoyl)oxy)methyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate), α-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-β-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate) (+11 more)
INCI: SUCROSE ACETATE ISOBUTYRATE
Sucrose Acetate Isobutyrate (CAS 126-13-6) is a cosmetic cosmetic ingredient functioning as Plasticizer, film former, viscosity controlling agent. NOAEL 2000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 126-13-6 →
Auto-generated CPSR Part A draft with source citations
Function
Plasticizer, film former, viscosity controlling agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(2R,3R,4S,5S)-5-(acetyloxymethyl)-5-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methylpropanoyloxy)oxan-2-yl]oxy-3,4-bis(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
InChIKey
UVGUPMLLGBCFEJ-SWTLDUCYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: Safe as used. Also GRAS as a direct food additive (21 CFR). Used in up to 31% concentration in eye shadow/foundation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sucrose Acetate Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sucrose Acetate Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 375 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 450 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 1200 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1290 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 2226 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2247 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2400 mg/kg bw/day | oral | monkey | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 2592 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2707 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sucrose Acetate Isobutyrate across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
SUCROSE ACETATE ISOBUTYRATE | 1996 | 0-20 mg/kg bw | TRS 868-JECFA 46/43 | FAS 32-JECFA 41/223
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Flavouring and nutrient
Plasticizer
Processing aids not otherwise specified
Solvent
Surface modifier
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sucrose Acetate Isobutyrate.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sucrose Acetate Isobutyrate by CAS number or substance name.
Studies
15
Lowest NOAEL
375 mg/kg bw/day
Highest NOAEL
10000 mg/kg bw/day
COSMOS_DB
Known Synonyms
Isobutyric acid, hexaester with sucrose diacetate
Sucrose, diacetate hexaisobutyrate
Sucrose acetate isobutanoate
(2R,3R,4S,5R,6R)-2-((Acetyloxy)methyl)-6-(((2S,3S,4R,5R)-5-((acetyloxy)methyl)-3,4-bis((2-methylpropanoyl)oxy)-2-(((2-methylpropanoyl)oxy)methyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate)
α-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-β-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate)
Sucrose acetoisobutyrate
EINECS 204-771-6
UNII-H5KI1C3YTV
Binester SAAB
SAIB
E 444
SAIB 100
SAIB 100S
Sustane SAIB MCT
EC No.: 204-771-6
204-771-6
Chemical Function
Film former
Plasticizer
Solvent
Flavouring and nutrient
Processing aids not otherwise specified
Surface modifier
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sucrose acetate isobutyrate
E Number
E444
ADI
20 mg/kg bw
FDA GRAS
FDA has no questions
GRN
104
Food Category
emulsifier
Use as a stabilizer of emulsions of flavoring oils in alcoholic beverages
View full food safety profile →Frequently Asked Questions
Is Sucrose Acetate Isobutyrate allowed in the EU?
Sucrose Acetate Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sucrose Acetate Isobutyrate do in cosmetics?
Sucrose Acetate Isobutyrate functions as: Plasticizer, film former, viscosity controlling agent. It is classified as a cosmetic ingredient in our database. CAS number: 126-13-6.
What is the NOAEL for Sucrose Acetate Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Sucrose Acetate Isobutyrate is 375 mg/kg bw/day based on a Short Term Toxicity study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Sucrose Acetate Isobutyrate used outside cosmetics?
Sucrose Acetate Isobutyrate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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