Is Spermidine safe in cosmetics?
Spermidine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Spermidine
Also known as: 1,4-Butanediamine, N-(3-aminopropyl)-, 1,4-Butanediamine, N1-(3-aminopropyl)-, Spermidin, N-(3-Aminopropyl)-4-aminobutylamine, 4-04-00-01300 (+10 more)
INCI: SPERMIDINE
Spermidine (CAS 124-20-9) is a cosmetic active ingredient functioning as skin-conditioning, anti-aging, autophagy-inducer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-20-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Spermidine is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
skin-conditioning, anti-aging, autophagy-inducer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N'-(3-aminopropyl)butane-1,4-diamine
InChIKey
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
OTC emerging cosmetic ingredient; endogenous polyamine; oral and topical research ongoing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Spermidine.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, cell-turnover", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Specialized res…
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "850", "estimated_cost_per_kg_usd_high": "1600", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "critical", "primary_source_region": "Europe/Japan", "bulk_discount_threshold_kg": "0.5", "seasonal_price_variation": "critical", "commodity_or_specialty": "specialty", "substitute_ingredients":…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Softener and conditioner
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Spermidine.
Regulatory Flags
autophagy-inducer
polyamine
age-declining
emerging-topical
longevity-research
ifra_fragrance
Known Synonyms
1,4-Butanediamine, N-(3-aminopropyl)-
1,4-Butanediamine, N1-(3-aminopropyl)-
Spermidin
N-(3-Aminopropyl)-4-aminobutylamine
4-04-00-01300
BRN 1698591
1,4-Diaminobutane, N-(3-aminopropyl)-
EINECS 204-689-0
UNII-U87FK77H25
(4-aminobutyl)(3-aminopropyl)amine
Aminopropylbutandiamine
N-(3-Aminopropyl)-1,4-diamino-butane
N-(3-aminopropyl)butane-1,4-diamine
N-(gamma-Aminopropyl)tetramethylenediamine
SPD
Chemical Function
Antioxidant
Softener and conditioner
Fragrance
Regulatory Lists
IFRA Transparency
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SPERMIDINE
ChEMBL ID
CHEMBL19612
Max Phase
3
Frequently Asked Questions
Is Spermidine allowed in the EU?
Spermidine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Spermidine do in cosmetics?
Spermidine functions as: skin-conditioning, anti-aging, autophagy-inducer. It is classified as a Active Ingredient in our database. CAS number: 124-20-9.
Is Spermidine used outside cosmetics?
Spermidine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Spermidine have different safety status in cosmetics vs industrial chemicals?
Spermidine is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Spermidine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
Excellent
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
Excellent
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
Excellent
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
Excellent
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
Excellent
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
Excellent
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
1,6-Hexanediamine
Poor
Chemical family
Industrial chemical (nylon monomer); ...
Adipic Acid
Excellent
Chemical family
Buffering
Aminomethyl Pro
Good
Chemical family
Insufficient Data
Is Spermidine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Spermidine in your formulation.