Is SORBITAN PALMITATE safe in cosmetics?
SORBITAN PALMITATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
SORBITAN PALMITATE
Also known as: Sorbitan, monohexadecanoate, EINECS 247-568-8, Emsorb 2510, Liposorb P, Nikkol SP10 (+6 more)
SORBITAN PALMITATE (CAS 26266-57-9) is a cosmetic cosmetic ingredient functioning as Surfactant - Emulsifying. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 26266-57-9 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant - Emulsifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate
InChIKey
IYFATESGLOUGBX-YVNJGZBMSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 38(S2):60-80,2019
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
emulsion_hlb
{"hlb_value": "6.7", "hlb_required_as_emulsifier": "yes", "emulsifier_type": "w_o", "critical_packing_parameter": "0.55-0.75", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "polysorbate_40,cetyl_alcohol", "optimal_oil_phase_pct": "45-75", "optimal_water_phase_pct": "25-55", "electrolyte_tolerance": "high", "pH_emulsion_stability_range": "5.0-9.0", "viscosity_bu…
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "hlb_value": "6.7", "soluble_in": "oils, ethanol", "insoluble_in": "water", "log_p": "3.9", "melting_point_c": "45-48", "appearance": "cream beads", "source": "Croda"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
SORBITAN MONOPALMITATE | 2020 | 0-25 mg/kg bw | Considered for specification only. Group ADI. As the sum of the sorbitan esters of lauric, oleic, palmitic and stearic acid. | TRS 1027-JECFA 89/44 | FAS 80-JECFA 89/221
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
Emulsifier
Surfactant (surface active agent)
Wetting agent (non-aqueous)
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for SORBITAN PALMITATE.
Regulatory Flags
cosing-sourced
eu-permitted
surfactant
needs-enrichment
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to SORBITAN PALMITATE by CAS number or substance name.
Studies
3
Lowest NOAEL
2600 mg/kg bw/day
Highest NOAEL
2600 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Sorbitan, monohexadecanoate
EINECS 247-568-8
Emsorb 2510
Liposorb P
Nikkol SP10
Nissan nonion PP40
Nonion PP40
Protachem SMP
Sorbitan palmitas
Sorbitani palmitas
UNII-77K6Z421KU
Chemical Function
Emulsifier
Surfactant (surface active agent)
Dispersing agent
Wetting agent (non-aqueous)
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
inert_ingredient; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
SCIL (9/2019)
pharmaceutical
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SORBITAN MONOPALMITATE
ChEMBL ID
CHEMBL3186294
Max Phase
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sorbitan monopalmitate
E Number
E495
ADI
25 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is SORBITAN PALMITATE allowed in the EU?
SORBITAN PALMITATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SORBITAN PALMITATE do in cosmetics?
SORBITAN PALMITATE functions as: Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 26266-57-9.
Is SORBITAN PALMITATE used outside cosmetics?
SORBITAN PALMITATE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check SORBITAN PALMITATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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