Is Solvent Red 72 safe in cosmetics?
Solvent Red 72 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Solvent Red 72
Also known as: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,4',5'-dibromo-3',6'-dihydroxy-, Fluorescein, 4',5'-dibromo-, 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, D & C Orange 5, D and C Orange No. 5 (+14 more)
INCI: CI 45370 (SOLVENT RED 72 / DIBROMOFLUORESCEIN)
Solvent Red 72 (CAS 596-03-2) is a cosmetic cosmetic ingredient functioning as Colorant — xanthene/halogenated fluorescein dye. Reported NOAEL =136.5 mg/kg bw/day in Mouse (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 596-03-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Solvent Red 72 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant — xanthene/halogenated fluorescein dye
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
InChIKey
ZDTNHRWWURISAA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Listed as D\&C Orange No. 5 — permitted for drug and cosmetic use with concentration restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Solvent Red 72.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Solvent Red 72. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =136.5 mg/kg bw/day | dermal | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rabbit | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Solvent Red 72.
Regulatory Flags
potential-allergen
colorant
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Solvent Red 72 by CAS number or substance name.
Studies
3
Lowest NOAEL
136.5 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,4',5'-dibromo-3',6'-dihydroxy-
Fluorescein, 4',5'-dibromo-
4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
D & C Orange 5
D and C Orange No. 5
D&C Orange No. 5
Orange No. 201
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-
4',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
C.I. 45370:1
D & C Orange No. 5
5-19-06-00462
BRN 0057189
EINECS 209-876-0
Eosinic acid
Japan Orange 201
Japan Orange No. 201
UNII-5P3H5X9X4Q
4',5'-Dibromofluorescein
Chemical Function
Dye
Regulatory Lists
pharmaceutical
Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561473
Frequently Asked Questions
Is Solvent Red 72 allowed in the EU?
Solvent Red 72 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Solvent Red 72 do in cosmetics?
Solvent Red 72 functions as: Colorant — xanthene/halogenated fluorescein dye. It is classified as a cosmetic ingredient in our database. CAS number: 596-03-2.
What is the NOAEL for Solvent Red 72?
The NOAEL (No Observed Adverse Effect Level) for Solvent Red 72 is =136.5 mg/kg bw/day based on a chronic study via dermal route in Mouse. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Solvent Red 72 used outside cosmetics?
Solvent Red 72 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Solvent Red 72 have different safety status in cosmetics vs industrial chemicals?
Solvent Red 72 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H412).
Compliance Tools
Check Solvent Red 72 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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