What is the NOAEL for C.I. Solvent Red 72?
C.I. Solvent Red 72 has 8 NOAEL studies in the database. The lowest reported value is 5P3H5X9X4Q UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Solvent Red 72
Also known as: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,4',5'-dibromo-3',6'-dihydroxy-, Fluorescein, 4',5'-dibromo-, 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, D & C Orange 5, D and C Orange No. 5 (+15 more)
CAS 596-03-2
C.I. Solvent Red 72 (CAS 596-03-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Solvent Red 72 is classified GHS Danger (H301, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Solvent Red 72
CAS Number
596-03-2
DTXSID
DTXSID7024904
Molecular Formula
C20H10Br2O5
InChI Key
ZDTNHRWWURISAA-UHFFFAOYSA-N
Monoisotopic Mass
487.889499
Synonyms
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,4',5'-dibromo-3',6'-dihydroxy-Fluorescein, 4',5'-dibromo-4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-oneD & C Orange 5D and C Orange No. 5D&C Orange No. 5Orange No. 201Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-4',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-oneC.I. 45370:1D & C Orange No. 55-19-06-00462
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5P3H5X9X4Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5P3H5X9X4Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5P3H5X9X4Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5P3H5X9X4Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =100 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =136.5 | mg/kg bw/day | NOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4',5'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one | 209-876-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3561473
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include C.I. Solvent Red 72?
C.I. Solvent Red 72 appears on 2 regulatory/inventory lists including pharmaceutical, Personal care. Source: EPA CPDat.
Is C.I. Solvent Red 72 used in cosmetics?
Yes, C.I. Solvent Red 72 is also indexed as a cosmetic ingredient under the name CI 45370. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Solvent Red 72 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Solvent Red 72 have different safety status in cosmetics vs industrial chemicals?
C.I. Solvent Red 72 is classified GHS Danger (H301, H412) in the chemicals database but is allowed in EU cosmetics.
Is C.I. Solvent Red 72 used outside industrial chemicals?
C.I. Solvent Red 72 also appears in cosmetics, pharmaceutical databases.