Is Sodium Heparin safe in cosmetics?
Sodium Heparin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Sodium Heparin
Also known as: Heparin, sodium salt, Adomiparin sodium, Dalteparin sodium, Deligoparin sodium, Liquaemin sodium (+12 more)
INCI: SODIUM HEPARIN
Sodium Heparin (CAS 9041-08-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning. Reported NOAEL =4 mg/kg bw/day in rat (Sprague-Dawley; male/female) (FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 9041-08-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Dual-use caution — heparin sodium is an FDA-approved drug (anticoagulant). Cosmetic use is permitted but must avoid drug claims
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Heparin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Sodium Heparin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =4 mg/kg bw/day | subcutaneous | rat (Sprague-Dawley; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =4 mg/kg bw/day | subcutaneous | rat (Sprague-Dawley; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =4 mg/kg bw/day | subcutaneous | rat (Sprague-Dawley; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =4 mg/kg bw/day | subcutaneous | rat (Sprague-Dawley; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =10 mg/kg bw/day | subcutaneous | dog (Beagle; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =10 mg/kg bw/day | subcutaneous | dog (Beagle; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =10 mg/kg bw/day | subcutaneous | dog (Beagle; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
| NOAEL | =10 mg/kg bw/day | subcutaneous | dog (Beagle; male/female) | repeated dose toxicity other | FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Heparin.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Heparin by CAS number or substance name.
Studies
8
Lowest NOAEL
4 mg/kg bw/day
Highest NOAEL
10 mg/kg bw/day
FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z
Known Synonyms
Heparin, sodium salt
Adomiparin sodium
Dalteparin sodium
Deligoparin sodium
Liquaemin sodium
Minolteparin sodium
Nadroparine sodium
Necuparanib sodium
Parnaparin sodium
Reviparin sodium
Semuloparin sodium
Sevuparin sodium
Sodium acid heparin
Sodium heparinate
Sodium parnaparin
Tinzaparin sodium
Ardeparin sodium
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
bemiparin
ChEMBL ID
CHEMBL1201414
Adverse Event Associations
3434
Frequently Asked Questions
Is Sodium Heparin allowed in the EU?
Sodium Heparin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Heparin do in cosmetics?
Sodium Heparin functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9041-08-1.
What is the NOAEL for Sodium Heparin?
The NOAEL (No Observed Adverse Effect Level) for Sodium Heparin is =4 mg/kg bw/day based on a repeated dose toxicity other study via subcutaneous route in rat (Sprague-Dawley; male/female). A total of 8 study endpoints are available. Source: FDA_Toxicity_040515be-0912-43d8-ab26-eeb1669a191e_dossier.i6z.
Is Sodium Heparin used outside cosmetics?
Sodium Heparin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Heparin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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