NOAEL Studies Cosmetic Ingredient

Sodium Ferrocyanide NOAEL Studies

INCI: SODIUM FERROCYANIDE

CAS: 13601-19-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =4.4 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2018 - OutputID 3063 - urinalysis - nephrotoxicity - Re-evaluation of sodium ferrocyanide (E 535), potassium ferrocyanide (E 536) and calcium ferrocyanide (E 538) as food additives - doi:10.2903/j.efsa.2018.5374
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =0.03 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2018 - OutputID 3063 - Consumers - Re-evaluation of sodium ferrocyanide (E 535), potassium ferrocyanide (E 536) and calcium ferrocyanide (E 538) as food additives - doi:10.2903/j.efsa.2018.5374
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =0.03 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2018 - OutputID 3063 - Consumers - Re-evaluation of sodium ferrocyanide (E 535), potassium ferrocyanide (E 536) and calcium ferrocyanide (E 538) as food additives - doi:10.2903/j.efsa.2018.5374
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=450 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b342a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14479/7/8?documentUUID=0af889f2-ae7f-44b7-931f-b09ea78692b9; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15820338:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51537982a423356a56dea3de0458eb25
ToxValDB_ECHA_IUCLID NOAEL =630 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b342a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14479/7/8?documentUUID=0af889f2-ae7f-44b7-931f-b09ea78692b9; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15820339:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4276e3ad3049b943857d4cbb98d45160
ToxValDB_ECHA_IUCLID NOAEL >=1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc33d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14479/7/9/3?documentUUID=0af889f2-ae7f-44b7-931f-b09ea78692b9; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15824319:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9fd9cd952191f95515794052262ed793
ToxValDB_ECHA_IUCLID NOAEL =4.4 mg/kg bw/day Rat oral chronic; 107 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c256a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12094?documentUUID=b300c255-029d-42ea-8cad-836bc333cae7; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|urinalysis|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837045_15848591:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60837b22ae8bb68f7466c537ea43eaa8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5HT6X21AID UNII - - - chemical {"approval_status":null,"molecular_formula":"6CN.Fe.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5HT6X21AID"}
openFDA substances FDA UNII substance identifier 5HT6X21AID UNII - - - chemical {"approval_status":null,"molecular_formula":"6CN.Fe.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5HT6X21AID"}
openFDA substances FDA UNII substance identifier 5HT6X21AID UNII - - - chemical {"approval_status":null,"molecular_formula":"6CN.Fe.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5HT6X21AID"}
openFDA substances FDA UNII substance identifier 5HT6X21AID UNII - - - chemical {"approval_status":null,"molecular_formula":"6CN.Fe.4Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5HT6X21AID"}