Is Sodium Ferrocyanide safe in cosmetics?
Sodium Ferrocyanide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Sodium Ferrocyanide
Also known as: Tetrasodium hexacyanoferrate, EINECS 237-081-9, Ferrate(4-), hexacyano-, tetrasodium, Sodium hexacyanoferate(II), Sodium prussiate yellow (+7 more)
INCI: SODIUM FERROCYANIDE
Sodium Ferrocyanide (CAS 13601-19-9) is a cosmetic cosmetic ingredient functioning as Anticaking agent. Reported NOAEL =630 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 13601-19-9 →
Auto-generated CPSR Part A draft with source citations
Function
Anticaking agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
tetrasodium;iron(2+);hexacyanide
InChIKey
GTSHREYGKSITGK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed as a color additive; permitted in food-grade salt as anticaking (E 535) — limited cosmetic use data
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Ferrocyanide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Sodium Ferrocyanide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =630 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (2)
JECFA Evaluation
HEXACYANOFERRATE OF SODIUM | 1974 | 0-0.025 mg/kg bw | NMRS 54/TRS 557-JECFA 18/23 | NMRS 54A/FAS 6-JECFA 18/164
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Ferrocyanide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Ferrocyanide by CAS number or substance name.
Studies
1
Lowest NOAEL
630 mg/kg bw/day
Highest NOAEL
630 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Tetrasodium hexacyanoferrate
EINECS 237-081-9
Ferrate(4-), hexacyano-, tetrasodium
Sodium hexacyanoferate(II)
Sodium prussiate yellow
Tetrasodium ferrocyanide
Tetrasodium hexacyanoferrate(4-)
UNII-5HT6X21AID
Na4[Fe(CN)6]
Natriumhexazyanoferrat(II)
sodium hexacyanoferrate(4-)
sodium hexacyanoferrate(II)
Chemical Function
Anti-caking agent
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Sodium Ferrocyanide allowed in the EU?
Sodium Ferrocyanide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Ferrocyanide do in cosmetics?
Sodium Ferrocyanide functions as: Anticaking agent. It is classified as a cosmetic ingredient in our database. CAS number: 13601-19-9.
What is the NOAEL for Sodium Ferrocyanide?
The NOAEL (No Observed Adverse Effect Level) for Sodium Ferrocyanide is =630 mg/kg bw/day based on a chronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Ferrocyanide used outside cosmetics?
Sodium Ferrocyanide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Ferrocyanide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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