Is Sodium Bisulfate safe in cosmetics?
Sodium Bisulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Sodium Bisulfate
Also known as: Caswell No. 742, EINECS 231-665-7, EPA Pesticide Chemical Code 073201, NSC 71192, Sodium bisulfate, fused (+5 more)
INCI: SODIUM BISULFATE
Sodium Bisulfate (CAS 7681-38-1) is a cosmetic cosmetic ingredient functioning as pH adjuster; buffering agent. NOAEL 2000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7681-38-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Bisulfate is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster; buffering agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium hydrogen sulfate
InChIKey
WBHQBSYUUJJSRZ-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.2%
US US Status
permitted
US Notes
GRAS (Generally Recognized as Safe) for food contact; permitted in cosmetics as pH adjuster; no specific FDA restriction for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Bisulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Bisulfate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Eye Dam. 1
Hazard Statements
- H318 Causes serious eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
SODIUM HYDROGEN SULFATE | 2009 | NOT SPECIFIED | TRS 956-JECFA 71 | FAS 62-JECFA 71
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Processing aids not otherwise specified
pH regulating agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Bisulfate.
Regulatory Flags
epa_safer_alternative
Known Synonyms
Caswell No. 742
EINECS 231-665-7
EPA Pesticide Chemical Code 073201
NSC 71192
Sodium bisulfate, fused
Sodium bisulfate, solid(DOT)
Sodium hydrogen sulfate, solid
Sodium pyrosulfate
Sodium sulfate, NaHSO4
UNII-BU8V88OWIQ
Chemical Function
pH regulating agent
Processing aids not otherwise specified
Biocide
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1200488
Frequently Asked Questions
Is Sodium Bisulfate allowed in the EU?
Sodium Bisulfate EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Bisulfate do in cosmetics?
Sodium Bisulfate functions as: pH adjuster; buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 7681-38-1.
Is Sodium Bisulfate used outside cosmetics?
Sodium Bisulfate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Bisulfate have different safety status in cosmetics vs industrial chemicals?
Sodium Bisulfate is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
Compliance Tools
Check Sodium Bisulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Cuprous Iodide
Poor
Chemical family
Not commonly used in cosmetics; theor...
NATAMYCIN
Good
Chemical family
Antimicrobial, Preservative
Phytic Acid Potassium Salt
Good
Chemical family
Chelating agent, skin conditioning
Is Sodium Bisulfate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Sodium Bisulfate in your formulation.