Danger GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Sodium hydrogen sulfate

Also known as: Sodium bisulfate, Caswell No. 742, EINECS 231-665-7, EPA Pesticide Chemical Code 073201, NSC 71192 (+6 more)

CAS 7681-38-1

Sodium hydrogen sulfate (CAS 7681-38-1) is a chemical substance with GHS signal word Danger; key hazard signal: H318. Key regulatory status: REACH registered, 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Sodium Bisulfate →

Cross-Vertical Regulatory Divergence

Sodium hydrogen sulfate is classified GHS Danger (H318) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Sodium hydrogen sulfate

CAS Number

7681-38-1

DTXSID

DTXSID3033983

Molecular Formula

Na.H2O4S

InChI Key

WBHQBSYUUJJSRZ-UHFFFAOYSA-M

Synonyms

Sodium bisulfateCaswell No. 742EINECS 231-665-7EPA Pesticide Chemical Code 073201NSC 71192Sodium bisulfate, fusedSodium bisulfate, solid(DOT)Sodium hydrogen sulfate, solidSodium pyrosulfateSodium sulfate, NaHSO4UNII-BU8V88OWIQ

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Dam. 1	H318	GHS05	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 14 records

pH regulating agentProcessing aids not otherwise specifiedBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 25 records

List	Keyword	Source
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Personal care; Southeast Asia	Asean	ASEAN Cosmetics
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
BU8V88OWIQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
BU8V88OWIQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
BU8V88OWIQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
BU8V88OWIQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
1	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
=8000	mg/kg bw/day	LEL	oral	Cow Family	ToxValDB_EFSA
4	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
10.7	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
14.6	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
83.4	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
100.1	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
103.7	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
31.7	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
35.9	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
44.1	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Sodium hydrogensulphate	231-665-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.2%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1200488

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 2 records

E514ii — FDA GRAS: FDA has no questions

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Sodium hydrogen sulfate?

Sodium hydrogen sulfate (CAS 7681-38-1) is classified under EU CLP Annex VI as Eye Dam. 1 with signal word Danger. Hazard statements: H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Sodium hydrogen sulfate?

Sodium hydrogen sulfate has 15 NOAEL studies in the database. The lowest reported value is BU8V88OWIQ UNII. Source: openFDA substances.

What regulatory lists include Sodium hydrogen sulfate?

Sodium hydrogen sulfate appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; Pesticides, CEDI, and 5 more. Source: EPA CPDat.

Is Sodium hydrogen sulfate used in cosmetics?

Yes, Sodium hydrogen sulfate is also indexed as a cosmetic ingredient under the name Sodium Bisulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium hydrogen sulfate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium hydrogen sulfate have different safety status in cosmetics vs industrial chemicals?

Sodium hydrogen sulfate is classified GHS Danger (H318) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

Is Sodium hydrogen sulfate used outside industrial chemicals?

Sodium hydrogen sulfate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.