Is Silybin safe in cosmetics?
Silybin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Silybin
Also known as: Silibinin, Silibinin A, Silybin b1, 4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-, Silymarin I (+13 more)
INCI: SILYBIN
Silybin (CAS 22888-70-6) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, anti-aging (major active flavonolignan from. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22888-70-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning, anti-aging (major active flavonolignan from milk thistle / *Silybum marianum*)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
InChIKey
SEBFKMXJBCUCAI-HKTJVKLFSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; GRAS-adjacent as a component of silymarin dietary supplements; permitted in cosmetics under general provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silybin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Silybin.
Known Synonyms
Silibinin
Silibinin A
Silybin b1
4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
Silymarin I
EINECS 245-302-5
Flavobin
Flavobin Spofa
Silliver
Silybine
Silymarine I
NSC 651520
Silibinina
Silibininum
UNII-33X338MNE4
Karsil
Silibinine
Silymarin
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SILYBIN A
ChEMBL ID
CHEMBL431701
Max Phase
3
Frequently Asked Questions
Is Silybin allowed in the EU?
Silybin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Silybin do in cosmetics?
Silybin functions as: Antioxidant, skin conditioning, anti-aging (major active flavonolignan from milk thistle / *Silybum marianum*). It is classified as a cosmetic ingredient in our database. CAS number: 22888-70-6.
Is Silybin used outside cosmetics?
Silybin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Silybin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Similar safety
Fragrance / Perfuming agent with flor...
SILICON
Good
Browse nearby
Abrasive
SILYBUM MARIANUM EXTRACT
Good
Browse nearby
Skin Conditioning
SIMMONDSIA CHINENSIS LEAF EXTRACT
Good
Browse nearby
Humectant
Is Silybin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Silybin in your formulation.