What is the NOAEL for Silybin?
Silybin has 4 NOAEL studies in the database. The lowest reported value is 33X338MNE4 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Silybin
Also known as: Silibinin, Silibinin A, Silybin b1, 4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-, Silymarin I (+13 more)
CAS 22888-70-6
Silybin (CAS 22888-70-6) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Silybin
CAS Number
22888-70-6
DTXSID
DTXSID8026018
Molecular Formula
C25H22O10
InChI Key
SEBFKMXJBCUCAI-HKTJVKLFSA-N
Monoisotopic Mass
482.121297
Synonyms
SilibininSilibinin ASilybin b14H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-Silymarin IEINECS 245-302-5FlavobinFlavobin SpofaSilliverSilybineSilymarine INSC 651520
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 33X338MNE4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33X338MNE4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33X338MNE4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33X338MNE4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SILYBIN A
ChEMBL Phase
3
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Silybin?
Silybin appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Silybin used in cosmetics?
Yes, Silybin is also indexed as a cosmetic ingredient under the name Silybin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Silybin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Silybin used outside industrial chemicals?
Silybin also appears in cosmetics, pharmaceutical databases.