Is Silver Chloride safe in cosmetics?
Silver Chloride has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Silver Chloride
Also known as: Caswell No. 735A, EINECS 232-033-3, EPA Pesticide Chemical Code 072506, Mark II, UNII-MWB0804EO7 (+2 more)
INCI: SILVER CHLORIDE
Silver Chloride (CAS 7783-90-6) is a cosmetic preservative functioning as Preservative (Antimicrobial). NOAEL 247.7 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.004% (as AgCl) - must be 20% AgCl w/w on TiO2 carrier. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7783-90-6 →
Auto-generated CPSR Part A draft with source citations
Function
Preservative (Antimicrobial)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
chlorosilver
InChIKey
HKZLPVFGJNLROG-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.004% (as AgCl) - must be 20% AgCl w/w on TiO2 carrier
US US Status
permitted
US Notes
No FDA monograph. No GRAS classification.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silver Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Silver Chloride across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Silver Chloride based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; SCCS
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Max: 0.004% (as AgCl)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (V - Preservatives)
Max: 0.004% (as AgCl).
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max 0,004% (expresso como cloreto de prata)
India: Permitted Preservative · max 0.004% (as AgCl)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.004 | all cosmetics except products for children <3yr, oral hygiene, eye products and lip products |
| BR | permitted_preservative | 0.004 (as AgCl) | 0.004% as AgCl (20% AgCl on TiO2 weight); not for children <3 yrs; not in oral products; not in eye area; not in lip products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "preservative", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; SCCS"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Preservative
Processing aids not otherwise specified
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Silver Chloride.
Regulatory Flags
EU_RESTRICTED
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Silver Chloride by CAS number or substance name.
Studies
30
Lowest NOAEL
0.34 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Caswell No. 735A
EINECS 232-033-3
EPA Pesticide Chemical Code 072506
Mark II
UNII-MWB0804EO7
AgCl
[AgCl]
Chemical Function
Preservative
No specific technical function
Processing aids not otherwise specified
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Indirect additives food contact (10/2018)
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4444164
Frequently Asked Questions
Is Silver Chloride allowed in the EU?
Silver Chloride EU regulatory status: restricted. Maximum allowed concentration: 0.004% (as AgCl) - must be 20% AgCl w/w on TiO2 carrier. This is based on EU Regulation 1223/2009 and its amendments.
What does Silver Chloride do in cosmetics?
Silver Chloride functions as: Preservative (Antimicrobial). It is classified as a Preservative in our database. CAS number: 7783-90-6.
Is Silver Chloride used outside cosmetics?
Silver Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Silver Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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